Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy

Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy

A variety of humanized mice, which are reconstituted only with human hematopoietic stem cells (HSC) or with fetal thymus and HSCs, have been developed and widely utilized as in vivo animal models of HIV-1 infection. The models represent some aspects of HIV-mediated pathogenesis in humans and are use...

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Bibliographic Details
Main Authors: Kazutaka Terahara, Ryutaro Iwabuchi, Yasuko Tsunetsugu-Yokota
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
humanized mice
non-BLT
immunological features
HIV infection
pathogenesis
therapy
Online Access:https://www.mdpi.com/1999-4915/13/5/776

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