The RUNX Family of Proteins, DNA Repair, and Cancer
The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and sol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/8/1106 |
| _version_ | 1797606006239264768 |
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| author | Vaidehi Krishnan |
| author_facet | Vaidehi Krishnan |
| author_sort | Vaidehi Krishnan |
| collection | DOAJ |
| description | The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and solid cancers by impairing DNA repair mechanisms. RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers. |
| first_indexed | 2024-03-11T05:09:15Z |
| format | Article |
| id | doaj.art-9208e14fd1f24dd2947721d2b9e5b399 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T05:09:15Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9208e14fd1f24dd2947721d2b9e5b3992023-11-17T18:42:37ZengMDPI AGCells2073-44092023-04-01128110610.3390/cells12081106The RUNX Family of Proteins, DNA Repair, and CancerVaidehi Krishnan0Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeThe RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and solid cancers by impairing DNA repair mechanisms. RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers.https://www.mdpi.com/2073-4409/12/8/1106RUNX1RUNX2RUNX3DNA repairleukemiaFanconi anemia |
| spellingShingle | Vaidehi Krishnan The RUNX Family of Proteins, DNA Repair, and Cancer Cells RUNX1 RUNX2 RUNX3 DNA repair leukemia Fanconi anemia |
| title | The RUNX Family of Proteins, DNA Repair, and Cancer |
| title_full | The RUNX Family of Proteins, DNA Repair, and Cancer |
| title_fullStr | The RUNX Family of Proteins, DNA Repair, and Cancer |
| title_full_unstemmed | The RUNX Family of Proteins, DNA Repair, and Cancer |
| title_short | The RUNX Family of Proteins, DNA Repair, and Cancer |
| title_sort | runx family of proteins dna repair and cancer |
| topic | RUNX1 RUNX2 RUNX3 DNA repair leukemia Fanconi anemia |
| url | https://www.mdpi.com/2073-4409/12/8/1106 |
| work_keys_str_mv | AT vaidehikrishnan therunxfamilyofproteinsdnarepairandcancer AT vaidehikrishnan runxfamilyofproteinsdnarepairandcancer |