Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception
The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/2/960 |
| _version_ | 1797493245860642816 |
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| author | Jean-Denis Troadec Stéphanie Gaigé Manon Barbot Bruno Lebrun Rym Barbouche Anne Abysique |
| author_facet | Jean-Denis Troadec Stéphanie Gaigé Manon Barbot Bruno Lebrun Rym Barbouche Anne Abysique |
| author_sort | Jean-Denis Troadec |
| collection | DOAJ |
| description | The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regulate nutritional balance. Until recently, research on the central regulation of food intake primarily focused on neuronal signaling, with little attention paid to the role of glial cells. Over the last few decades, our understanding of glial cells has changed dramatically. These cells are increasingly regarded as important neuronal partners, contributing not just to cerebral homeostasis, but also to cerebral signaling. Our understanding of the central regulation of energy balance is part of this (r)evolution. Evidence is accumulating that glial cells play a dynamic role in the modulation of energy balance. In the present review, we summarize recent data indicating that the multifaceted glial compartment of the brainstem dorsal vagal complex (DVC) should be considered in research aimed at identifying feeding-related processes operating at this level. |
| first_indexed | 2024-03-10T01:17:16Z |
| format | Article |
| id | doaj.art-920b87cc2cdd48f0b31ab77d0082f621 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:17:16Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-920b87cc2cdd48f0b31ab77d0082f6212023-11-23T14:07:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123296010.3390/ijms23020960Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No ExceptionJean-Denis Troadec0Stéphanie Gaigé1Manon Barbot2Bruno Lebrun3Rym Barbouche4Anne Abysique5Laboratoire de Neurosciences Cognitives, Campus St Charles, Université Aix Marseille, UMR CNRS 7291, 13331 Marseille, FranceLaboratoire de Neurosciences Cognitives, Campus St Charles, Université Aix Marseille, UMR CNRS 7291, 13331 Marseille, FranceLaboratoire de Neurosciences Cognitives, Campus St Charles, Université Aix Marseille, UMR CNRS 7291, 13331 Marseille, FranceLaboratoire de Neurosciences Cognitives, Campus St Charles, Université Aix Marseille, UMR CNRS 7291, 13331 Marseille, FranceLaboratoire de Neurosciences Cognitives, Campus St Charles, Université Aix Marseille, UMR CNRS 7291, 13331 Marseille, FranceLaboratoire de Neurosciences Cognitives, Campus St Charles, Université Aix Marseille, UMR CNRS 7291, 13331 Marseille, FranceThe avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regulate nutritional balance. Until recently, research on the central regulation of food intake primarily focused on neuronal signaling, with little attention paid to the role of glial cells. Over the last few decades, our understanding of glial cells has changed dramatically. These cells are increasingly regarded as important neuronal partners, contributing not just to cerebral homeostasis, but also to cerebral signaling. Our understanding of the central regulation of energy balance is part of this (r)evolution. Evidence is accumulating that glial cells play a dynamic role in the modulation of energy balance. In the present review, we summarize recent data indicating that the multifaceted glial compartment of the brainstem dorsal vagal complex (DVC) should be considered in research aimed at identifying feeding-related processes operating at this level.https://www.mdpi.com/1422-0067/23/2/960metabolismfood intakeobesityNTSarea postremaastrocytes |
| spellingShingle | Jean-Denis Troadec Stéphanie Gaigé Manon Barbot Bruno Lebrun Rym Barbouche Anne Abysique Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception International Journal of Molecular Sciences metabolism food intake obesity NTS area postrema astrocytes |
| title | Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception |
| title_full | Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception |
| title_fullStr | Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception |
| title_full_unstemmed | Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception |
| title_short | Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception |
| title_sort | glial modulation of energy balance the dorsal vagal complex is no exception |
| topic | metabolism food intake obesity NTS area postrema astrocytes |
| url | https://www.mdpi.com/1422-0067/23/2/960 |
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