Pharmacologic Inhibition of Myostatin With a Myostatin Antibody Improves the Skeletal Muscle and Bone Phenotype of Male Insulin‐Deficient Diabetic Mice

Pharmacologic Inhibition of Myostatin With a Myostatin Antibody Improves the Skeletal Muscle and Bone Phenotype of Male Insulin‐Deficient Diabetic Mice

ABSTRACT Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bone formation. We investigated whether pharmacologi...

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Bibliographic Details
Main Authors: R Clay Bunn, Reuben Adatorwovor, Rebecca R Smith, Philip D Ray, Sarah E Fields, Alexander R Keeble, Christopher S Fry, Sasidhar Uppuganti, Jeffry S Nyman, John L Fowlkes, Evangelia Kalaitzoglou
Format: Article
Language:English
Published: Oxford University Press 2023-11-01
Series:JBMR Plus
Subjects:
BONE
MUSCLE
MYOSTATIN
TYPE 1 DIABETES MELLITUS
Online Access:https://doi.org/10.1002/jbm4.10833

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