Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration
Physical stimuli play an important role in one tissue engineering. Mechanical stimuli, such as ultrasound with cyclic loading, are widely used to promote bone osteogenesis; however, the inflammatory response under physical stimuli has not been well studied. In this paper, the signaling pathways rela...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/3/169 |
| _version_ | 1797610961846140928 |
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| author | Junjie Wang Bo Yuan Ruixue Yin Hongbo Zhang |
| author_facet | Junjie Wang Bo Yuan Ruixue Yin Hongbo Zhang |
| author_sort | Junjie Wang |
| collection | DOAJ |
| description | Physical stimuli play an important role in one tissue engineering. Mechanical stimuli, such as ultrasound with cyclic loading, are widely used to promote bone osteogenesis; however, the inflammatory response under physical stimuli has not been well studied. In this paper, the signaling pathways related to inflammatory responses in bone tissue engineering are evaluated, and the application of physical stimulation to promote osteogenesis and its related mechanisms are reviewed in detail; in particular, how physical stimulation alleviates inflammatory responses during transplantation when employing a bone scaffolding strategy is discussed. It is concluded that physical stimulation (e.g., ultrasound and cyclic stress) helps to promote osteogenesis while reducing the inflammatory response. In addition, apart from 2D cell culture, more consideration should be given to the mechanical stimuli applied to 3D scaffolds and the effects of different force moduli while evaluating inflammatory responses. This will facilitate the application of physiotherapy in bone tissue engineering. |
| first_indexed | 2024-03-11T06:21:19Z |
| format | Article |
| id | doaj.art-9211e7871e7f4dfbb0cf7886db1a0832 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T06:21:19Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-9211e7871e7f4dfbb0cf7886db1a08322023-11-17T11:54:33ZengMDPI AGJournal of Functional Biomaterials2079-49832023-03-0114316910.3390/jfb14030169Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone RegenerationJunjie Wang0Bo Yuan1Ruixue Yin2Hongbo Zhang3School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, ChinaSpine Center, Department of Orthopaedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, ChinaSchool of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, ChinaSchool of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, ChinaPhysical stimuli play an important role in one tissue engineering. Mechanical stimuli, such as ultrasound with cyclic loading, are widely used to promote bone osteogenesis; however, the inflammatory response under physical stimuli has not been well studied. In this paper, the signaling pathways related to inflammatory responses in bone tissue engineering are evaluated, and the application of physical stimulation to promote osteogenesis and its related mechanisms are reviewed in detail; in particular, how physical stimulation alleviates inflammatory responses during transplantation when employing a bone scaffolding strategy is discussed. It is concluded that physical stimulation (e.g., ultrasound and cyclic stress) helps to promote osteogenesis while reducing the inflammatory response. In addition, apart from 2D cell culture, more consideration should be given to the mechanical stimuli applied to 3D scaffolds and the effects of different force moduli while evaluating inflammatory responses. This will facilitate the application of physiotherapy in bone tissue engineering.https://www.mdpi.com/2079-4983/14/3/169inflammationmechanical environmentbone regenerationultrasoundmechanical force |
| spellingShingle | Junjie Wang Bo Yuan Ruixue Yin Hongbo Zhang Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration Journal of Functional Biomaterials inflammation mechanical environment bone regeneration ultrasound mechanical force |
| title | Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration |
| title_full | Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration |
| title_fullStr | Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration |
| title_full_unstemmed | Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration |
| title_short | Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration |
| title_sort | inflammation responses to bone scaffolds under mechanical stimuli in bone regeneration |
| topic | inflammation mechanical environment bone regeneration ultrasound mechanical force |
| url | https://www.mdpi.com/2079-4983/14/3/169 |
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