Immune Actions on the Peripheral Nervous System in Pain
Pain can be induced by tissue injuries, diseases and infections. The interactions between the peripheral nervous system (PNS) and immune system are primary actions in pain sensitizations. In response to stimuli, nociceptors release various mediators from their terminals that potently activate and re...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/3/1448 |
| _version_ | 1797416947009191936 |
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| author | Jessica Aijia Liu Jing Yu Chi Wai Cheung |
| author_facet | Jessica Aijia Liu Jing Yu Chi Wai Cheung |
| author_sort | Jessica Aijia Liu |
| collection | DOAJ |
| description | Pain can be induced by tissue injuries, diseases and infections. The interactions between the peripheral nervous system (PNS) and immune system are primary actions in pain sensitizations. In response to stimuli, nociceptors release various mediators from their terminals that potently activate and recruit immune cells, whereas infiltrated immune cells further promote sensitization of nociceptors and the transition from acute to chronic pain by producing cytokines, chemokines, lipid mediators and growth factors. Immune cells not only play roles in pain production but also contribute to PNS repair and pain resolution by secreting anti-inflammatory or analgesic effectors. Here, we discuss the distinct roles of four major types of immune cells (monocyte/macrophage, neutrophil, mast cell, and T cell) acting on the PNS during pain process. Integration of this current knowledge will enhance our understanding of cellular changes and molecular mechanisms underlying pain pathogenies, providing insights for developing new therapeutic strategies. |
| first_indexed | 2024-03-09T06:11:44Z |
| format | Article |
| id | doaj.art-9213134d0e004e7cb6bdd1d23be39e03 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T06:11:44Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9213134d0e004e7cb6bdd1d23be39e032023-12-03T11:58:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01223144810.3390/ijms22031448Immune Actions on the Peripheral Nervous System in PainJessica Aijia Liu0Jing Yu1Chi Wai Cheung2Laboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong 102, ChinaLaboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong 102, ChinaLaboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong 102, ChinaPain can be induced by tissue injuries, diseases and infections. The interactions between the peripheral nervous system (PNS) and immune system are primary actions in pain sensitizations. In response to stimuli, nociceptors release various mediators from their terminals that potently activate and recruit immune cells, whereas infiltrated immune cells further promote sensitization of nociceptors and the transition from acute to chronic pain by producing cytokines, chemokines, lipid mediators and growth factors. Immune cells not only play roles in pain production but also contribute to PNS repair and pain resolution by secreting anti-inflammatory or analgesic effectors. Here, we discuss the distinct roles of four major types of immune cells (monocyte/macrophage, neutrophil, mast cell, and T cell) acting on the PNS during pain process. Integration of this current knowledge will enhance our understanding of cellular changes and molecular mechanisms underlying pain pathogenies, providing insights for developing new therapeutic strategies.https://www.mdpi.com/1422-0067/22/3/1448peripheral nervous systempainimmune responseinflammation |
| spellingShingle | Jessica Aijia Liu Jing Yu Chi Wai Cheung Immune Actions on the Peripheral Nervous System in Pain International Journal of Molecular Sciences peripheral nervous system pain immune response inflammation |
| title | Immune Actions on the Peripheral Nervous System in Pain |
| title_full | Immune Actions on the Peripheral Nervous System in Pain |
| title_fullStr | Immune Actions on the Peripheral Nervous System in Pain |
| title_full_unstemmed | Immune Actions on the Peripheral Nervous System in Pain |
| title_short | Immune Actions on the Peripheral Nervous System in Pain |
| title_sort | immune actions on the peripheral nervous system in pain |
| topic | peripheral nervous system pain immune response inflammation |
| url | https://www.mdpi.com/1422-0067/22/3/1448 |
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