Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study
<b>Background:</b> In this study, we aimed to assess the factors that predict a dysfunctional conditioned pain modulation (CPM) in chronic knee OA. <b>Methods:</b> This is a cross-sectional analysis of patients with chronic knee OA from a prospective cohort study in Brazil (n...
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MDPI AG
2023-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/8/1697 |
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| author | Marcel Simis Kevin Pacheco-Barrios Karen Vasquez-Avila Ingrid Rebello-Sanchez Joao Parente Luis Castelo-Branco Anna Marduy Paulo S. de Melo Marta Imamura Linamara Battistella Felipe Fregni |
| author_facet | Marcel Simis Kevin Pacheco-Barrios Karen Vasquez-Avila Ingrid Rebello-Sanchez Joao Parente Luis Castelo-Branco Anna Marduy Paulo S. de Melo Marta Imamura Linamara Battistella Felipe Fregni |
| author_sort | Marcel Simis |
| collection | DOAJ |
| description | <b>Background:</b> In this study, we aimed to assess the factors that predict a dysfunctional conditioned pain modulation (CPM) in chronic knee OA. <b>Methods:</b> This is a cross-sectional analysis of patients with chronic knee OA from a prospective cohort study in Brazil (n = 85). We performed linear and logistic multivariate regression models using the purposeful selection approach to test the relationship between the CPM in both knees (average) as a dependent variable and demographics, clinical, and neurophysiological as independent variables. <b>Results:</b> A significant negative association between WOMAC pain scores and CPM (β: −0.13) was found. This association was modified by the subjects’ race, being stronger in the non-white subjects. In our logistic regression models, pain intensity indexed with the WOMAC pain scale remained a significant association with dichotomized CPM. Furthermore, a significant CPM association with balance, indexed with the Berg Balance score, was evidenced (β: 0.04). Neurophysiological variables showed a significant negative relationship with CPM, such as the relative power of delta oscillations in the frontal area (β: −3.11) and central area (β: −3.23). There was no significant relationship between CPM and the following domains: cognitive, emotion, sleep, opioid receptor polymorphisms, and intrinsic variables of OA disease. There was no association of CPM with TMS-indexed inhibitory markers. <b>Conclusions:</b> These results may indicate that less function of the pain descending inhibitory system in patients with OA is correlated with higher activity-related pain (WOMAC), less balance, and cortical plasticity especially with increased low-frequency (delta) brain oscillations. These associations seem modified by race. |
| first_indexed | 2024-03-10T23:47:42Z |
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| language | English |
| last_indexed | 2024-03-10T23:47:42Z |
| publishDate | 2023-08-01 |
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| series | Life |
| spelling | doaj.art-92137871267b43fd9411872ddef2ba572023-11-19T01:54:18ZengMDPI AGLife2075-17292023-08-01138169710.3390/life13081697Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional StudyMarcel Simis0Kevin Pacheco-Barrios1Karen Vasquez-Avila2Ingrid Rebello-Sanchez3Joao Parente4Luis Castelo-Branco5Anna Marduy6Paulo S. de Melo7Marta Imamura8Linamara Battistella9Felipe Fregni10Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo 01002, BrazilNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USANeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USANeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USANeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USANeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USANeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USANeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USAFaculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo 01002, BrazilFaculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo 01002, BrazilNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA<b>Background:</b> In this study, we aimed to assess the factors that predict a dysfunctional conditioned pain modulation (CPM) in chronic knee OA. <b>Methods:</b> This is a cross-sectional analysis of patients with chronic knee OA from a prospective cohort study in Brazil (n = 85). We performed linear and logistic multivariate regression models using the purposeful selection approach to test the relationship between the CPM in both knees (average) as a dependent variable and demographics, clinical, and neurophysiological as independent variables. <b>Results:</b> A significant negative association between WOMAC pain scores and CPM (β: −0.13) was found. This association was modified by the subjects’ race, being stronger in the non-white subjects. In our logistic regression models, pain intensity indexed with the WOMAC pain scale remained a significant association with dichotomized CPM. Furthermore, a significant CPM association with balance, indexed with the Berg Balance score, was evidenced (β: 0.04). Neurophysiological variables showed a significant negative relationship with CPM, such as the relative power of delta oscillations in the frontal area (β: −3.11) and central area (β: −3.23). There was no significant relationship between CPM and the following domains: cognitive, emotion, sleep, opioid receptor polymorphisms, and intrinsic variables of OA disease. There was no association of CPM with TMS-indexed inhibitory markers. <b>Conclusions:</b> These results may indicate that less function of the pain descending inhibitory system in patients with OA is correlated with higher activity-related pain (WOMAC), less balance, and cortical plasticity especially with increased low-frequency (delta) brain oscillations. These associations seem modified by race.https://www.mdpi.com/2075-1729/13/8/1697conditioned pain modulationosteoarthritispainracebalance |
| spellingShingle | Marcel Simis Kevin Pacheco-Barrios Karen Vasquez-Avila Ingrid Rebello-Sanchez Joao Parente Luis Castelo-Branco Anna Marduy Paulo S. de Melo Marta Imamura Linamara Battistella Felipe Fregni Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study Life conditioned pain modulation osteoarthritis pain race balance |
| title | Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study |
| title_full | Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study |
| title_fullStr | Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study |
| title_full_unstemmed | Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study |
| title_short | Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study |
| title_sort | functional and neural correlates associated with conditioned pain modulation in patients with chronic knee osteoarthritis pain a cross sectional study |
| topic | conditioned pain modulation osteoarthritis pain race balance |
| url | https://www.mdpi.com/2075-1729/13/8/1697 |
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