Role of renal replacement therapy in pregnancy related acute kidney injury and its outcome
Background: Pregnancy-related acute kidney injury (PRAKI) has bimodal distribution. The rates of maternal mortality and perinatal mortality in patients with PRAKI have increased. The aim of this study was to evaluate magnitude of PRAKI in North Indian women and to assess morbidity, mortality, and ou...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=5;spage=2155;epage=2161;aulast=Sachan |
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| author | Rekha Sachan Savita Shukla Radhey Shyam Munna Lal Patel Manju Lata Verma |
| author_facet | Rekha Sachan Savita Shukla Radhey Shyam Munna Lal Patel Manju Lata Verma |
| author_sort | Rekha Sachan |
| collection | DOAJ |
| description | Background: Pregnancy-related acute kidney injury (PRAKI) has bimodal distribution. The rates of maternal mortality and perinatal mortality in patients with PRAKI have increased. The aim of this study was to evaluate magnitude of PRAKI in North Indian women and to assess morbidity, mortality, and outcomes in patients who received renal replacement therapy. Materials and Methods: This prospective observational study was carried out in the Department of Obstetrics and Gynaecology, in collaboration with nephrology. A total of 150 women suffering from PRAKI were recruited and total 98 obstetrics AKI, requiring renal replacement therapy, classified as per KDIGO guidelines 2012 were enrolled for dialysis. Six patients were lost to follow up before final analysis. Haemodialysis was carried out by B. Brawn machine. Results: Approximately 82% cases of PRAKI diagnosed in postpartum period. Mean cycles of dialysis was 9.06 ± 7.75 approximately half of the females required 1–5 cycles of dialysis. Higher percentages of maternal deaths were observed within 1–5 cycles of dialysis. Women received dialysis after 72 h showed increased chances of partial recovery. After 3 months of follow-up, rate of complete recovery was significantly higher in Stage I (100%) and Stage II (84.6%) PRAKI while rate of partial recovery and deaths were significantly higher in Stage III PRAKI (37.3%). Stage of AKI, baseline K+ levels, treatment modality, duration of ICU stay and use of Vasopressure showed significant association with adverse outcome. Conclusion: Higher percentages of deaths were observed in those who referred late and delay in initiation of dialysis and it was observed within 1–5 cycles of dialysis. |
| first_indexed | 2024-04-12T14:05:37Z |
| format | Article |
| id | doaj.art-9214b3a46b1242e7ac90aaa203d6fa92 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-04-12T14:05:37Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-9214b3a46b1242e7ac90aaa203d6fa922022-12-22T03:30:05ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632022-01-011152155216110.4103/jfmpc.jfmpc_1019_21Role of renal replacement therapy in pregnancy related acute kidney injury and its outcomeRekha SachanSavita ShuklaRadhey ShyamMunna Lal PatelManju Lata VermaBackground: Pregnancy-related acute kidney injury (PRAKI) has bimodal distribution. The rates of maternal mortality and perinatal mortality in patients with PRAKI have increased. The aim of this study was to evaluate magnitude of PRAKI in North Indian women and to assess morbidity, mortality, and outcomes in patients who received renal replacement therapy. Materials and Methods: This prospective observational study was carried out in the Department of Obstetrics and Gynaecology, in collaboration with nephrology. A total of 150 women suffering from PRAKI were recruited and total 98 obstetrics AKI, requiring renal replacement therapy, classified as per KDIGO guidelines 2012 were enrolled for dialysis. Six patients were lost to follow up before final analysis. Haemodialysis was carried out by B. Brawn machine. Results: Approximately 82% cases of PRAKI diagnosed in postpartum period. Mean cycles of dialysis was 9.06 ± 7.75 approximately half of the females required 1–5 cycles of dialysis. Higher percentages of maternal deaths were observed within 1–5 cycles of dialysis. Women received dialysis after 72 h showed increased chances of partial recovery. After 3 months of follow-up, rate of complete recovery was significantly higher in Stage I (100%) and Stage II (84.6%) PRAKI while rate of partial recovery and deaths were significantly higher in Stage III PRAKI (37.3%). Stage of AKI, baseline K+ levels, treatment modality, duration of ICU stay and use of Vasopressure showed significant association with adverse outcome. Conclusion: Higher percentages of deaths were observed in those who referred late and delay in initiation of dialysis and it was observed within 1–5 cycles of dialysis.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=5;spage=2155;epage=2161;aulast=Sachanhaemodialysisintensive carepregnancy related acute kidney injuryrecoveryrenal replacement therapy |
| spellingShingle | Rekha Sachan Savita Shukla Radhey Shyam Munna Lal Patel Manju Lata Verma Role of renal replacement therapy in pregnancy related acute kidney injury and its outcome Journal of Family Medicine and Primary Care haemodialysis intensive care pregnancy related acute kidney injury recovery renal replacement therapy |
| title | Role of renal replacement therapy in pregnancy related acute kidney injury and its outcome |
| title_full | Role of renal replacement therapy in pregnancy related acute kidney injury and its outcome |
| title_fullStr | Role of renal replacement therapy in pregnancy related acute kidney injury and its outcome |
| title_full_unstemmed | Role of renal replacement therapy in pregnancy related acute kidney injury and its outcome |
| title_short | Role of renal replacement therapy in pregnancy related acute kidney injury and its outcome |
| title_sort | role of renal replacement therapy in pregnancy related acute kidney injury and its outcome |
| topic | haemodialysis intensive care pregnancy related acute kidney injury recovery renal replacement therapy |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=5;spage=2155;epage=2161;aulast=Sachan |
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