A-Kinase Anchoring Proteins Diminish TGF-β<sub>1</sub>/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition

A-Kinase Anchoring Proteins Diminish TGF-β<sub>1</sub>/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition

Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-&#946;1 (TGF-&#946;1) mediated EMT. Although compartmentalization via A-kinase anchoring proteins (AKAPs) is...

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Bibliographic Details
Main Authors: Haoxiao Zuo, Marina Trombetta-Lima, Irene H. Heijink, Christina H. T. J. van der Veen, Laura Hesse, Klaas Nico Faber, Wilfred J. Poppinga, Harm Maarsingh, Viacheslav O. Nikolaev, Martina Schmidt
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
epithelial-to-mesenchymal transition
tgf-β1
camp
a-kinase anchoring protein
ezrin
akap95
yotiao
cigarette smoke
copd
Online Access:https://www.mdpi.com/2073-4409/9/2/356

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