Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that represents <5% of all thyroid malignancies and is generally more aggressive than differentiated thyroid cancer. The aim of this study is to provide an update, through review of clinical studies of patients with MTC published between...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-10-01
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| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/20420188211049611 |
| _version_ | 1818403906445639680 |
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| author | Marisa A. Bartz-Kurycki Omowunmi E. Oluwo Lilah F. Morris-Wiseman |
| author_facet | Marisa A. Bartz-Kurycki Omowunmi E. Oluwo Lilah F. Morris-Wiseman |
| author_sort | Marisa A. Bartz-Kurycki |
| collection | DOAJ |
| description | Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that represents <5% of all thyroid malignancies and is generally more aggressive than differentiated thyroid cancer. The aim of this study is to provide an update, through review of clinical studies of patients with MTC published between January 1, 2016, and June 1, 2021, on recent advances in the diagnosis and treatment of MTC. This review focuses on updates in biochemical testing, imaging, hereditary disease, surgical management, adjuvant therapies, and prognosis. Recent advances reviewed herein have sought to diagnose MTC at earlier stages of disease, predict when patients with a hereditary syndrome may develop MTC, use functional imaging to assess for distant metastases, perform optimal initial surgery with appropriate lymphadenectomy, employ targeted systemic therapies for patients with progressive metastatic disease, and better predict patient-specific outcomes. |
| first_indexed | 2024-12-14T08:31:42Z |
| format | Article |
| id | doaj.art-9215b203170e4628a7e38d67f45ea47b |
| institution | Directory Open Access Journal |
| issn | 2042-0196 |
| language | English |
| last_indexed | 2024-12-14T08:31:42Z |
| publishDate | 2021-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj.art-9215b203170e4628a7e38d67f45ea47b2022-12-21T23:09:30ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01962021-10-011210.1177/20420188211049611Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosisMarisa A. Bartz-KuryckiOmowunmi E. OluwoLilah F. Morris-WisemanMedullary thyroid carcinoma (MTC) is a neuroendocrine tumor that represents <5% of all thyroid malignancies and is generally more aggressive than differentiated thyroid cancer. The aim of this study is to provide an update, through review of clinical studies of patients with MTC published between January 1, 2016, and June 1, 2021, on recent advances in the diagnosis and treatment of MTC. This review focuses on updates in biochemical testing, imaging, hereditary disease, surgical management, adjuvant therapies, and prognosis. Recent advances reviewed herein have sought to diagnose MTC at earlier stages of disease, predict when patients with a hereditary syndrome may develop MTC, use functional imaging to assess for distant metastases, perform optimal initial surgery with appropriate lymphadenectomy, employ targeted systemic therapies for patients with progressive metastatic disease, and better predict patient-specific outcomes.https://doi.org/10.1177/20420188211049611 |
| spellingShingle | Marisa A. Bartz-Kurycki Omowunmi E. Oluwo Lilah F. Morris-Wiseman Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis Therapeutic Advances in Endocrinology and Metabolism |
| title | Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis |
| title_full | Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis |
| title_fullStr | Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis |
| title_full_unstemmed | Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis |
| title_short | Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis |
| title_sort | medullary thyroid carcinoma recent advances in identification treatment and prognosis |
| url | https://doi.org/10.1177/20420188211049611 |
| work_keys_str_mv | AT marisaabartzkurycki medullarythyroidcarcinomarecentadvancesinidentificationtreatmentandprognosis AT omowunmieoluwo medullarythyroidcarcinomarecentadvancesinidentificationtreatmentandprognosis AT lilahfmorriswiseman medullarythyroidcarcinomarecentadvancesinidentificationtreatmentandprognosis |