Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model

Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model

Abstract Background Off-the-shelf major histocompatibility complex (MHC)-matched iPS cells (iPSC) can potentially initiate host immune responses because of the existence of numerous minor antigens. To suppress allo-immune responses, combination of immunosuppressants is usually used, but its efficacy...

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Bibliographic Details
Main Authors: Tomoki Kamatani, Ryo Otsuka, Tomoki Murata, Haruka Wada, Takeshi Takahashi, Akihiro Mori, Soichiro Murata, Hideki Taniguchi, Ken-ichiro Seino
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Inflammation and Regeneration
Subjects:
iPS cell transplantation
Transplantation immunology
MHC-matched
Minor antigen
Immunosuppressive agents
Costimulatory molecule blockade
Online Access:https://doi.org/10.1186/s41232-021-00190-7

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