Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma
Senescence can have beneficial and detrimental impact on cancer progression depending on the cellular context. Here the authors show that NRF2 regulates the senescence phenotype in malignant cells which consequently contribute to glioblastoma progression.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36124-9 |
| _version_ | 1811175759211921408 |
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| author | Rana Salam Alexa Saliou Franck Bielle Mathilde Bertrand Christophe Antoniewski Catherine Carpentier Agusti Alentorn Laurent Capelle Marc Sanson Emmanuelle Huillard Léa Bellenger Justine Guégan Isabelle Le Roux |
| author_facet | Rana Salam Alexa Saliou Franck Bielle Mathilde Bertrand Christophe Antoniewski Catherine Carpentier Agusti Alentorn Laurent Capelle Marc Sanson Emmanuelle Huillard Léa Bellenger Justine Guégan Isabelle Le Roux |
| author_sort | Rana Salam |
| collection | DOAJ |
| description | Senescence can have beneficial and detrimental impact on cancer progression depending on the cellular context. Here the authors show that NRF2 regulates the senescence phenotype in malignant cells which consequently contribute to glioblastoma progression. |
| first_indexed | 2024-04-10T19:42:09Z |
| format | Article |
| id | doaj.art-921a4435b8f04a829da3f93afb4e6978 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T19:42:09Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-921a4435b8f04a829da3f93afb4e69782023-01-29T12:16:44ZengNature PortfolioNature Communications2041-17232023-01-0114112110.1038/s41467-023-36124-9Cellular senescence in malignant cells promotes tumor progression in mouse and patient GlioblastomaRana Salam0Alexa Saliou1Franck Bielle2Mathilde Bertrand3Christophe Antoniewski4Catherine Carpentier5Agusti Alentorn6Laurent Capelle7Marc Sanson8Emmanuelle Huillard9Léa Bellenger10Justine Guégan11Isabelle Le Roux12Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamParis Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamParis Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamParis Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Data Analysis Core PlatformSorbonne Université, CNRS FR3631, Inserm US037, Institut de Biologie Paris Seine (IBPS), ARTbio Bioinformatics Analysis Facility, Paris, Institut Français de Bioinformatique (IFB)Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamParis Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamAP-HP, Hôpital de la Pitié-Salpêtrière—Charles Foix, Service de NeurochirurgieParis Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamParis Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamSorbonne Université, CNRS FR3631, Inserm US037, Institut de Biologie Paris Seine (IBPS), ARTbio Bioinformatics Analysis Facility, Paris, Institut Français de Bioinformatique (IFB)Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Data Analysis Core PlatformParis Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors TeamSenescence can have beneficial and detrimental impact on cancer progression depending on the cellular context. Here the authors show that NRF2 regulates the senescence phenotype in malignant cells which consequently contribute to glioblastoma progression.https://doi.org/10.1038/s41467-023-36124-9 |
| spellingShingle | Rana Salam Alexa Saliou Franck Bielle Mathilde Bertrand Christophe Antoniewski Catherine Carpentier Agusti Alentorn Laurent Capelle Marc Sanson Emmanuelle Huillard Léa Bellenger Justine Guégan Isabelle Le Roux Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma Nature Communications |
| title | Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma |
| title_full | Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma |
| title_fullStr | Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma |
| title_full_unstemmed | Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma |
| title_short | Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma |
| title_sort | cellular senescence in malignant cells promotes tumor progression in mouse and patient glioblastoma |
| url | https://doi.org/10.1038/s41467-023-36124-9 |
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