A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video
This study aimed to determine the correlation of the parameters that indicate the status of the ocular surface with the prognosis of corneal opacification. Fifty dogs (96 eyes) were examined using a grid-line illuminator (non-invasive tear film break-up time (NIBUT)). Thirty dogs (54 eyes) were incl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1298467/full |
| _version_ | 1797219262648025088 |
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| author | Suk Jun Lee Myeong Gyun Han Su-Jung Yang Yun-Soo Choi Joon Young Kim Joon Young Kim |
| author_facet | Suk Jun Lee Myeong Gyun Han Su-Jung Yang Yun-Soo Choi Joon Young Kim Joon Young Kim |
| author_sort | Suk Jun Lee |
| collection | DOAJ |
| description | This study aimed to determine the correlation of the parameters that indicate the status of the ocular surface with the prognosis of corneal opacification. Fifty dogs (96 eyes) were examined using a grid-line illuminator (non-invasive tear film break-up time (NIBUT)). Thirty dogs (54 eyes) were included in the final analysis based on the criteria. The NIBUT and tear film break-up time (TFBUT) results of the eyes included in the study were divided into three groups: Group 1 (< 5 s), Group 2 (5 to <10 s), and Group 3 (≥ 10 s). The Schirmer’s tear Test 1 (STT-1) results of the included patients were also divided into three groups: Group 1 (< 5 mm/min), Group 2 (5 to <10 mm/min), and Group 3 (≥ 10 mm/min). The corneal opacity grades are divided into four scores, ranging from 0 to 3. The corneal opacity grade score (COS) of 0 indicates a completely clear cornea or only a trace of opacity. COS of 1, 2, 3 indicate the presence of a prominent corneal opacity that does not interfere with the visualization of the fine iris details, the opacity obscures the visibility of the iris and lens details and severe obstruction of the intraocular structure visibility, respectively. The mean difference in COS during the follow-ups for each group of NIBUT were 0.61 ± 0.92 (n = 28), 0.10 ± 0.32 (n = 10), 0.19 ± 0.40 (n = 16). The NIBUT groups were significantly correlated with COS (p-value = 0.073) at a 10% level of significance. Post-hoc test at a 10% level of significance revealed significant correlations between Groups 1 and 2 (p-value = 0.041) and between Groups 1 and 3 (p-value 0.104). Although the TFBUT and STT-1 groups did not show any significant correlation with COS. Eyes with NIBUT of <5 s were found to have a significantly higher chance of increased COS compared with eyes with NIBUT of >5 s in the grid-line illumination plate NIBUT test. Among NIBUT, STT-1, and TFBUT, NIBUT was the only test that showed significant associations with the changes in COS. |
| first_indexed | 2024-04-24T12:30:51Z |
| format | Article |
| id | doaj.art-921b7e2c80b24784b4b4a4a1a617fccd |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-24T12:30:51Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-921b7e2c80b24784b4b4a4a1a617fccd2024-04-08T04:54:14ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-04-011110.3389/fvets.2024.12984671298467A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging videoSuk Jun Lee0Myeong Gyun Han1Su-Jung Yang2Yun-Soo Choi3Joon Young Kim4Joon Young Kim5Division of Business Administration, College of Business, Kwangwoon University, Seoul, Republic of KoreaDepartment of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of KoreaDepartment of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of KoreaDepartment of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of KoreaDepartment of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of KoreaKU Center for Animal Blood Medical Science, Konkuk University, Seoul, Republic of KoreaThis study aimed to determine the correlation of the parameters that indicate the status of the ocular surface with the prognosis of corneal opacification. Fifty dogs (96 eyes) were examined using a grid-line illuminator (non-invasive tear film break-up time (NIBUT)). Thirty dogs (54 eyes) were included in the final analysis based on the criteria. The NIBUT and tear film break-up time (TFBUT) results of the eyes included in the study were divided into three groups: Group 1 (< 5 s), Group 2 (5 to <10 s), and Group 3 (≥ 10 s). The Schirmer’s tear Test 1 (STT-1) results of the included patients were also divided into three groups: Group 1 (< 5 mm/min), Group 2 (5 to <10 mm/min), and Group 3 (≥ 10 mm/min). The corneal opacity grades are divided into four scores, ranging from 0 to 3. The corneal opacity grade score (COS) of 0 indicates a completely clear cornea or only a trace of opacity. COS of 1, 2, 3 indicate the presence of a prominent corneal opacity that does not interfere with the visualization of the fine iris details, the opacity obscures the visibility of the iris and lens details and severe obstruction of the intraocular structure visibility, respectively. The mean difference in COS during the follow-ups for each group of NIBUT were 0.61 ± 0.92 (n = 28), 0.10 ± 0.32 (n = 10), 0.19 ± 0.40 (n = 16). The NIBUT groups were significantly correlated with COS (p-value = 0.073) at a 10% level of significance. Post-hoc test at a 10% level of significance revealed significant correlations between Groups 1 and 2 (p-value = 0.041) and between Groups 1 and 3 (p-value 0.104). Although the TFBUT and STT-1 groups did not show any significant correlation with COS. Eyes with NIBUT of <5 s were found to have a significantly higher chance of increased COS compared with eyes with NIBUT of >5 s in the grid-line illumination plate NIBUT test. Among NIBUT, STT-1, and TFBUT, NIBUT was the only test that showed significant associations with the changes in COS.https://www.frontiersin.org/articles/10.3389/fvets.2024.1298467/fullnon-invasive break-up timetear film break-up timeocular surface diseasedry eye diseasecorneal opacification |
| spellingShingle | Suk Jun Lee Myeong Gyun Han Su-Jung Yang Yun-Soo Choi Joon Young Kim Joon Young Kim A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video Frontiers in Veterinary Science non-invasive break-up time tear film break-up time ocular surface disease dry eye disease corneal opacification |
| title | A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video |
| title_full | A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video |
| title_fullStr | A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video |
| title_full_unstemmed | A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video |
| title_short | A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video |
| title_sort | novel method of evaluating the non invasive tear film break up time and progression of corneal opacification in dogs using imaging video |
| topic | non-invasive break-up time tear film break-up time ocular surface disease dry eye disease corneal opacification |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1298467/full |
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