Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective Study
Nocturnal and circadian intraocular pressure (IOP) fluctuations are important issues in glaucoma treatment. Ripasudil 0.4% eye drops, a new glaucoma medication, lowers IOP by increasing aqueous humor outflow through the trabecular meshwork. We aimed to compare differences between circadian IOP fluct...
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MDPI AG
2023-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/5/800 |
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| author | Shih-Kung Huang Mai Ishii Yuki Mizuki Tatukata Kawagoe Masaki Takeuchi Eiichi Nomura Nobuhisa Mizuki |
| author_facet | Shih-Kung Huang Mai Ishii Yuki Mizuki Tatukata Kawagoe Masaki Takeuchi Eiichi Nomura Nobuhisa Mizuki |
| author_sort | Shih-Kung Huang |
| collection | DOAJ |
| description | Nocturnal and circadian intraocular pressure (IOP) fluctuations are important issues in glaucoma treatment. Ripasudil 0.4% eye drops, a new glaucoma medication, lowers IOP by increasing aqueous humor outflow through the trabecular meshwork. We aimed to compare differences between circadian IOP fluctuations measured using a contact lens sensor (CLS) before and after administering 0.4% ripasudil eye drops adjunctively to patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Patients with POAG (<i>n</i> = 1) and NTG (<i>n</i> = 5) underwent 24 h IOP monitoring with a CLS before and after administering ripasudil eye drops every 12 h (8 a.m., 8 p.m.) for 2 weeks without discontinuing currently used glaucoma medications. No vision-threatening adverse event occurred. The reduction in IOP fluctuation and the reduction in the SD of IOP in 24 h, awake time and sleep time did not reach statistical significance. The baseline office-hour IOP, which was measured using Goldmann applanation tonometry (GAT), ranged in the low teens, and the reduction in office-hour IOP also did not show a significant difference. Further study is necessary to evaluate whether the low baseline IOP with less IOP reduction relates to attenuated IOP fluctuation reduction. |
| first_indexed | 2024-03-11T03:35:39Z |
| format | Article |
| id | doaj.art-921c51c355eb45a8b438d5cca890284a |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T03:35:39Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-921c51c355eb45a8b438d5cca890284a2023-11-18T02:04:18ZengMDPI AGJournal of Personalized Medicine2075-44262023-05-0113580010.3390/jpm13050800Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective StudyShih-Kung Huang0Mai Ishii1Yuki Mizuki2Tatukata Kawagoe3Masaki Takeuchi4Eiichi Nomura5Nobuhisa Mizuki6Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanNocturnal and circadian intraocular pressure (IOP) fluctuations are important issues in glaucoma treatment. Ripasudil 0.4% eye drops, a new glaucoma medication, lowers IOP by increasing aqueous humor outflow through the trabecular meshwork. We aimed to compare differences between circadian IOP fluctuations measured using a contact lens sensor (CLS) before and after administering 0.4% ripasudil eye drops adjunctively to patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Patients with POAG (<i>n</i> = 1) and NTG (<i>n</i> = 5) underwent 24 h IOP monitoring with a CLS before and after administering ripasudil eye drops every 12 h (8 a.m., 8 p.m.) for 2 weeks without discontinuing currently used glaucoma medications. No vision-threatening adverse event occurred. The reduction in IOP fluctuation and the reduction in the SD of IOP in 24 h, awake time and sleep time did not reach statistical significance. The baseline office-hour IOP, which was measured using Goldmann applanation tonometry (GAT), ranged in the low teens, and the reduction in office-hour IOP also did not show a significant difference. Further study is necessary to evaluate whether the low baseline IOP with less IOP reduction relates to attenuated IOP fluctuation reduction.https://www.mdpi.com/2075-4426/13/5/800circadian IOP fluctuationcontact lens sensorglaucomaintraocular pressureripasudil |
| spellingShingle | Shih-Kung Huang Mai Ishii Yuki Mizuki Tatukata Kawagoe Masaki Takeuchi Eiichi Nomura Nobuhisa Mizuki Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective Study Journal of Personalized Medicine circadian IOP fluctuation contact lens sensor glaucoma intraocular pressure ripasudil |
| title | Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective Study |
| title_full | Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective Study |
| title_fullStr | Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective Study |
| title_full_unstemmed | Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective Study |
| title_short | Circadian Fluctuation Changes in Intraocular Pressure Measured Using a Contact Lens Sensor in Patients with Glaucoma after the Adjunctive Administration of Ripasudil: A Prospective Study |
| title_sort | circadian fluctuation changes in intraocular pressure measured using a contact lens sensor in patients with glaucoma after the adjunctive administration of ripasudil a prospective study |
| topic | circadian IOP fluctuation contact lens sensor glaucoma intraocular pressure ripasudil |
| url | https://www.mdpi.com/2075-4426/13/5/800 |
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