Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes
Chronic cough is a common symptom of many childhood lung conditions. Given the phenotypic heterogeneity of chronic cough, better characterization through endotyping is required to provide diagnostic certainty, precision therapies and to identify pathobiological mechanisms. This review summarizes rec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/3/756 |
| _version_ | 1797318609609949184 |
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| author | Hannah E. O’Farrell Hing Cheong Kok Suhani Goel Anne B. Chang Stephanie T. Yerkovich |
| author_facet | Hannah E. O’Farrell Hing Cheong Kok Suhani Goel Anne B. Chang Stephanie T. Yerkovich |
| author_sort | Hannah E. O’Farrell |
| collection | DOAJ |
| description | Chronic cough is a common symptom of many childhood lung conditions. Given the phenotypic heterogeneity of chronic cough, better characterization through endotyping is required to provide diagnostic certainty, precision therapies and to identify pathobiological mechanisms. This review summarizes recent endotype discoveries in airway diseases, particularly in relation to children, and describes the multi-omic approaches that are required to define endotypes. Potential biospecimens that may contribute to endotype and biomarker discoveries are also discussed. Identifying endotypes of chronic cough can likely provide personalized medicine and contribute to improved clinical outcomes for children. |
| first_indexed | 2024-03-08T03:53:50Z |
| format | Article |
| id | doaj.art-921c72288cab43bf9c6689d7b05273af |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T03:53:50Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-921c72288cab43bf9c6689d7b05273af2024-02-09T15:15:55ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113375610.3390/jcm13030756Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical OutcomesHannah E. O’Farrell0Hing Cheong Kok1Suhani Goel2Anne B. Chang3Stephanie T. Yerkovich4NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, AustraliaNHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, AustraliaAustralian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4000, AustraliaNHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, AustraliaNHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, AustraliaChronic cough is a common symptom of many childhood lung conditions. Given the phenotypic heterogeneity of chronic cough, better characterization through endotyping is required to provide diagnostic certainty, precision therapies and to identify pathobiological mechanisms. This review summarizes recent endotype discoveries in airway diseases, particularly in relation to children, and describes the multi-omic approaches that are required to define endotypes. Potential biospecimens that may contribute to endotype and biomarker discoveries are also discussed. Identifying endotypes of chronic cough can likely provide personalized medicine and contribute to improved clinical outcomes for children.https://www.mdpi.com/2077-0383/13/3/756coughchildrenreviewendotypesmulti-omicsbiomarkers |
| spellingShingle | Hannah E. O’Farrell Hing Cheong Kok Suhani Goel Anne B. Chang Stephanie T. Yerkovich Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes Journal of Clinical Medicine cough children review endotypes multi-omics biomarkers |
| title | Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes |
| title_full | Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes |
| title_fullStr | Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes |
| title_full_unstemmed | Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes |
| title_short | Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes |
| title_sort | endotypes of paediatric cough do they exist and finding new techniques to improve clinical outcomes |
| topic | cough children review endotypes multi-omics biomarkers |
| url | https://www.mdpi.com/2077-0383/13/3/756 |
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