Clinicopathological study and outcomes of primary extranodal lymphoma
Lymphoma can present with either lymphadenopathy or extranodal involvement. There are limited clinicopathological data pertaining to the occurrence of primary extranodal lymphoma (pENL) in Thailand. This was a retrospective study conducted at Chiang-Mai University Hospital from 2012 to 2016. Patient...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-11-01
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| Series: | Hematology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/8227 |
| _version_ | 1797936760843403264 |
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| author | Nichapa Nanthakwang Ekarat Rattarittamrong Thanawat Rattanathammethee Chatree Chai-Adisaksopha Adisak Tantiworawit Lalita Norasetthada Charin Ya-In |
| author_facet | Nichapa Nanthakwang Ekarat Rattarittamrong Thanawat Rattanathammethee Chatree Chai-Adisaksopha Adisak Tantiworawit Lalita Norasetthada Charin Ya-In |
| author_sort | Nichapa Nanthakwang |
| collection | DOAJ |
| description | Lymphoma can present with either lymphadenopathy or extranodal involvement. There are limited clinicopathological data pertaining to the occurrence of primary extranodal lymphoma (pENL) in Thailand. This was a retrospective study conducted at Chiang-Mai University Hospital from 2012 to 2016. Patients 18 years of age and over and with a diagnosis of pENL were enrolled onto study. Data related to clinical presentations, histology, stage, treatment and response were collected. There were 104 pENL patients with a median age of 63 years included. The most common presentation was gastrointestinal symptoms (41%), followed by ear, nose, and throat symptoms (35%). Diffuse large B-cell lymphoma (DLBCL) was the most common morphological subtype (60%), followed by marginal zone lymphoma (15%). The majority of patients presented with stage II disease (55%). The five-year overall survival rate was 71%. The factors associated with mortality were hemoglobin <7 g/dL, B-symptoms and LDH above upper normal limits. This study illustrated that lymphoma can present at various extranodal sites. Gastrointestinal symptoms were the most common presentations and DLBCL was the most common subtype of pENL. |
| first_indexed | 2024-04-10T18:35:05Z |
| format | Article |
| id | doaj.art-921c817e96594b0d8e0489b2c537abc3 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:35:05Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-921c817e96594b0d8e0489b2c537abc32023-02-02T01:46:55ZengMDPI AGHematology Reports2038-83222038-83302019-11-0111410.4081/hr.2019.8227Clinicopathological study and outcomes of primary extranodal lymphomaNichapa Nanthakwang0Ekarat Rattarittamrong1Thanawat Rattanathammethee2Chatree Chai-Adisaksopha3Adisak Tantiworawit4Lalita Norasetthada5Charin Ya-In6Department of Internal Medicine, Chiang MaiDepartment of Internal Medicine, Chiang MaiDepartment of Internal Medicine, Chiang MaiDepartment of Internal Medicine, Chiang MaiDepartment of Internal Medicine, Chiang MaiDepartment of Internal Medicine, Chiang MaiDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang MaiLymphoma can present with either lymphadenopathy or extranodal involvement. There are limited clinicopathological data pertaining to the occurrence of primary extranodal lymphoma (pENL) in Thailand. This was a retrospective study conducted at Chiang-Mai University Hospital from 2012 to 2016. Patients 18 years of age and over and with a diagnosis of pENL were enrolled onto study. Data related to clinical presentations, histology, stage, treatment and response were collected. There were 104 pENL patients with a median age of 63 years included. The most common presentation was gastrointestinal symptoms (41%), followed by ear, nose, and throat symptoms (35%). Diffuse large B-cell lymphoma (DLBCL) was the most common morphological subtype (60%), followed by marginal zone lymphoma (15%). The majority of patients presented with stage II disease (55%). The five-year overall survival rate was 71%. The factors associated with mortality were hemoglobin <7 g/dL, B-symptoms and LDH above upper normal limits. This study illustrated that lymphoma can present at various extranodal sites. Gastrointestinal symptoms were the most common presentations and DLBCL was the most common subtype of pENL.https://www.pagepress.org/journals/index.php/hr/article/view/8227Extranodal lymphoma; Lymphoma; Diffuse large B-cell lymphoma, Marginal zone lymphoma |
| spellingShingle | Nichapa Nanthakwang Ekarat Rattarittamrong Thanawat Rattanathammethee Chatree Chai-Adisaksopha Adisak Tantiworawit Lalita Norasetthada Charin Ya-In Clinicopathological study and outcomes of primary extranodal lymphoma Hematology Reports Extranodal lymphoma; Lymphoma; Diffuse large B-cell lymphoma, Marginal zone lymphoma |
| title | Clinicopathological study and outcomes of primary extranodal lymphoma |
| title_full | Clinicopathological study and outcomes of primary extranodal lymphoma |
| title_fullStr | Clinicopathological study and outcomes of primary extranodal lymphoma |
| title_full_unstemmed | Clinicopathological study and outcomes of primary extranodal lymphoma |
| title_short | Clinicopathological study and outcomes of primary extranodal lymphoma |
| title_sort | clinicopathological study and outcomes of primary extranodal lymphoma |
| topic | Extranodal lymphoma; Lymphoma; Diffuse large B-cell lymphoma, Marginal zone lymphoma |
| url | https://www.pagepress.org/journals/index.php/hr/article/view/8227 |
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