Upright proton therapy for esthesioneuroblastoma: a single-institution experience
AimThis study presents an analysis (efficacy and toxicity) of outcomes in patients with esthesioneuroblastoma after pencil beam proton therapy with a fixed beamline in the upright position.BackgroundEsthesioneuroblastoma (ENB) is an extremely rare tumor of sinonasal area located in critical proximit...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1348291/full |
| _version_ | 1827369137480925184 |
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| author | Konstantin Gordon Konstantin Gordon Igor Gulidov Daniil Smyk Daniil Smyk Alexey Semenov Kirill Golubev Alyona Lemaeva Sergey Koryakin Enar Jumaniyazova Polina Vishnyakova Irina Eremina Timur Fatkhudinov Andrey Kaprin Andrey Kaprin |
| author_facet | Konstantin Gordon Konstantin Gordon Igor Gulidov Daniil Smyk Daniil Smyk Alexey Semenov Kirill Golubev Alyona Lemaeva Sergey Koryakin Enar Jumaniyazova Polina Vishnyakova Irina Eremina Timur Fatkhudinov Andrey Kaprin Andrey Kaprin |
| author_sort | Konstantin Gordon |
| collection | DOAJ |
| description | AimThis study presents an analysis (efficacy and toxicity) of outcomes in patients with esthesioneuroblastoma after pencil beam proton therapy with a fixed beamline in the upright position.BackgroundEsthesioneuroblastoma (ENB) is an extremely rare tumor of sinonasal area located in critical proximity to vital structures. Proton therapy (PT) is often considered the optimal radiation treatment for head-and-neck tumors, although of limited availability. Upright PT delivered using fixed pencil beamline and rotating chair is a fairly promising option.MethodsThis is a single-center experience describing the outcomes of PT in 14 patients with ENB treated between January 2016 and October 2022; half of the cases had a history of previous irradiation. The therapy was applied using a fixed pencil beamline with 6D-chair for positioning. The median dose was 63 GyRBE (total range 48–70 GyRBE; based on 1.1 RBE multiplier for protons) with 2.0 GyRBE per fraction. The mean gross tumor volume was 109.5 cm3 (17.1–257.7 cm3). Patient demography, pathology, treatment parameters and toxicity data were analyzed. Radiation-induced reactions were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) v 4.0.ResultsThe median follow-up time was 28 months. The 1- and 2-year locoregional control rates constituted 100% and 88.9%, respectively; the median duration of local control was 52 months. The 1- and 2-year progression-free survival (PFS) rates constituted 92.9% and 75.0%, respectively; the median PFS duration was 52 months. The 1- and 2-year overall survival (OS) rates constituted 92.9% and 84.4%, respectively. Two patients died of non-cancer-related causes (coronavirus-induced pneumonia) and 1 patient died of tumor progression. All patients tolerated PT well without any treatment gaps. Serious late toxicity reactions included glaucoma in 1 patient and cataract in 2 patients, in over half a year since irradiation.ConclusionPT with upright design of the unit affords promising outcomes in terms of disease control and toxicity rates in ENB, a sinonasal tumor of complicated localization. |
| first_indexed | 2024-03-08T09:41:56Z |
| format | Article |
| id | doaj.art-921d4224102e446a91733dc1cd442cf3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T09:41:56Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-921d4224102e446a91733dc1cd442cf32024-01-30T04:15:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011410.3389/fonc.2024.13482911348291Upright proton therapy for esthesioneuroblastoma: a single-institution experienceKonstantin Gordon0Konstantin Gordon1Igor Gulidov2Daniil Smyk3Daniil Smyk4Alexey Semenov5Kirill Golubev6Alyona Lemaeva7Sergey Koryakin8Enar Jumaniyazova9Polina Vishnyakova10Irina Eremina11Timur Fatkhudinov12Andrey Kaprin13Andrey Kaprin14Proton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaResearch Institute of Molecular and Cellular Medicine, Medical Institution, P. Lumumba People’s Friendship University of Russia, Moscow, RussiaProton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaProton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaResearch Institute of Molecular and Cellular Medicine, Medical Institution, P. Lumumba People’s Friendship University of Russia, Moscow, RussiaProton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaProton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaProton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaProton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaResearch Institute of Molecular and Cellular Medicine, Medical Institution, P. Lumumba People’s Friendship University of Russia, Moscow, RussiaResearch Institute of Molecular and Cellular Medicine, Medical Institution, P. Lumumba People’s Friendship University of Russia, Moscow, RussiaResearch Institute of Molecular and Cellular Medicine, Medical Institution, P. Lumumba People’s Friendship University of Russia, Moscow, RussiaResearch Institute of Molecular and Cellular Medicine, Medical Institution, P. Lumumba People’s Friendship University of Russia, Moscow, RussiaProton Therapy Department, A. Tsyb Medical Radiological Research Center - Branch of the National Medical Radiological Research Center, Obninsk, RussiaResearch Institute of Molecular and Cellular Medicine, Medical Institution, P. Lumumba People’s Friendship University of Russia, Moscow, RussiaAimThis study presents an analysis (efficacy and toxicity) of outcomes in patients with esthesioneuroblastoma after pencil beam proton therapy with a fixed beamline in the upright position.BackgroundEsthesioneuroblastoma (ENB) is an extremely rare tumor of sinonasal area located in critical proximity to vital structures. Proton therapy (PT) is often considered the optimal radiation treatment for head-and-neck tumors, although of limited availability. Upright PT delivered using fixed pencil beamline and rotating chair is a fairly promising option.MethodsThis is a single-center experience describing the outcomes of PT in 14 patients with ENB treated between January 2016 and October 2022; half of the cases had a history of previous irradiation. The therapy was applied using a fixed pencil beamline with 6D-chair for positioning. The median dose was 63 GyRBE (total range 48–70 GyRBE; based on 1.1 RBE multiplier for protons) with 2.0 GyRBE per fraction. The mean gross tumor volume was 109.5 cm3 (17.1–257.7 cm3). Patient demography, pathology, treatment parameters and toxicity data were analyzed. Radiation-induced reactions were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) v 4.0.ResultsThe median follow-up time was 28 months. The 1- and 2-year locoregional control rates constituted 100% and 88.9%, respectively; the median duration of local control was 52 months. The 1- and 2-year progression-free survival (PFS) rates constituted 92.9% and 75.0%, respectively; the median PFS duration was 52 months. The 1- and 2-year overall survival (OS) rates constituted 92.9% and 84.4%, respectively. Two patients died of non-cancer-related causes (coronavirus-induced pneumonia) and 1 patient died of tumor progression. All patients tolerated PT well without any treatment gaps. Serious late toxicity reactions included glaucoma in 1 patient and cataract in 2 patients, in over half a year since irradiation.ConclusionPT with upright design of the unit affords promising outcomes in terms of disease control and toxicity rates in ENB, a sinonasal tumor of complicated localization.https://www.frontiersin.org/articles/10.3389/fonc.2024.1348291/fullesthesioneuroblastomaproton therapyradiation therapyreirradiationbrain invasionupright position |
| spellingShingle | Konstantin Gordon Konstantin Gordon Igor Gulidov Daniil Smyk Daniil Smyk Alexey Semenov Kirill Golubev Alyona Lemaeva Sergey Koryakin Enar Jumaniyazova Polina Vishnyakova Irina Eremina Timur Fatkhudinov Andrey Kaprin Andrey Kaprin Upright proton therapy for esthesioneuroblastoma: a single-institution experience Frontiers in Oncology esthesioneuroblastoma proton therapy radiation therapy reirradiation brain invasion upright position |
| title | Upright proton therapy for esthesioneuroblastoma: a single-institution experience |
| title_full | Upright proton therapy for esthesioneuroblastoma: a single-institution experience |
| title_fullStr | Upright proton therapy for esthesioneuroblastoma: a single-institution experience |
| title_full_unstemmed | Upright proton therapy for esthesioneuroblastoma: a single-institution experience |
| title_short | Upright proton therapy for esthesioneuroblastoma: a single-institution experience |
| title_sort | upright proton therapy for esthesioneuroblastoma a single institution experience |
| topic | esthesioneuroblastoma proton therapy radiation therapy reirradiation brain invasion upright position |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1348291/full |
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