Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma
ObjectivesThe objectives of this study were to assess the changes in the left myocardial function after chemotherapy for childhood lymphoma and observe the predictive or monitor value for cancer treatment-related cardiac dysfunction (CTRCD) by speckle-tracking echocardiography.MethodsA total of 23 c...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1163664/full |
| _version_ | 1797833053787127808 |
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| author | Jiaqi Chen Chunyue Cheng Li Fan Xiaochuan Xu Jing Chen Yang Feng Yi Tang Chunjiang Yang |
| author_facet | Jiaqi Chen Chunyue Cheng Li Fan Xiaochuan Xu Jing Chen Yang Feng Yi Tang Chunjiang Yang |
| author_sort | Jiaqi Chen |
| collection | DOAJ |
| description | ObjectivesThe objectives of this study were to assess the changes in the left myocardial function after chemotherapy for childhood lymphoma and observe the predictive or monitor value for cancer treatment-related cardiac dysfunction (CTRCD) by speckle-tracking echocardiography.MethodsA total of 23 children with histopathological diagnoses of lymphoma were included, with age-matched normal controls. Comparative analysis of clinical serological tests and left heart strain parameters in children with lymphoma, including left ventricular global longitudinal strain (LVGLS); global myocardial work (GMW) indices, which include global work index (GWI), global constructive work (GCW), global wasted work, and global work efficiency; and the LS of subendocardial, middle, and subepicardial layer myocardium during left ventricular systole were measured: left atrial strain of reservoir phase (LASr), left atrial strain of conduit phase (LAScd), and left atrial strain of contraction phase (LASct).ResultsOne-way ANOVA showed that GLS, GWI, GCW, LASr, and LAScd were closely associated with CTRCD and multivariate logistic regression analysis showed that GLS was the most sensitive predictor for detecting patients at lofty risk of anthracycline-related cardiotoxicity. Both before and after chemotherapy, GLS in the left ventricle showed a pattern of basal segment < middle segment < apical segment and subepicardial < middle < subendocardial layer (p < 0.05), and the degree of decrease also showed a regular pattern of epicardial layer < middle layer < subendocardial layer while the difference was not significant (p > 0.05). After chemotherapy, maximum flow rate in early mitral relaxation/left atrial systolic maximum flow rate (E/A) and left atrial volume index of each group were in the normal range, and the values of LASr, LAScd, and LASct slightly increased in the second cycle and decreased significantly in the fourth cycle after chemotherapy, reaching the lowest level; LASr and LAScd were positively correlated with GLS.ConclusionLVGLS is a more sensitive and earlier indicator to predict CTRCD compared with conventional echocardiography-related parameters and serological markers, and GLS of each myocardial layer showed a certain regularity. Left atrial strain can be used for early monitoring of cardiotoxicity in children with lymphoma after chemotherapy. |
| first_indexed | 2024-04-09T14:18:37Z |
| format | Article |
| id | doaj.art-921dad47ac114d49bcfe04e17c120719 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T14:18:37Z |
| publishDate | 2023-05-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-921dad47ac114d49bcfe04e17c1207192023-05-05T05:50:31ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-05-011110.3389/fped.2023.11636641163664Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphomaJiaqi Chen0Chunyue Cheng1Li Fan2Xiaochuan Xu3Jing Chen4Yang Feng5Yi Tang6Chunjiang Yang7Department of Ultrasound, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaDepartment of Ultrasound, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ultrasound, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaDepartment of Ultrasound, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaDepartment of Ultrasound, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaDepartment of Ultrasound, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaDepartment of Ultrasound, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaDepartment of Ultrasound, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaObjectivesThe objectives of this study were to assess the changes in the left myocardial function after chemotherapy for childhood lymphoma and observe the predictive or monitor value for cancer treatment-related cardiac dysfunction (CTRCD) by speckle-tracking echocardiography.MethodsA total of 23 children with histopathological diagnoses of lymphoma were included, with age-matched normal controls. Comparative analysis of clinical serological tests and left heart strain parameters in children with lymphoma, including left ventricular global longitudinal strain (LVGLS); global myocardial work (GMW) indices, which include global work index (GWI), global constructive work (GCW), global wasted work, and global work efficiency; and the LS of subendocardial, middle, and subepicardial layer myocardium during left ventricular systole were measured: left atrial strain of reservoir phase (LASr), left atrial strain of conduit phase (LAScd), and left atrial strain of contraction phase (LASct).ResultsOne-way ANOVA showed that GLS, GWI, GCW, LASr, and LAScd were closely associated with CTRCD and multivariate logistic regression analysis showed that GLS was the most sensitive predictor for detecting patients at lofty risk of anthracycline-related cardiotoxicity. Both before and after chemotherapy, GLS in the left ventricle showed a pattern of basal segment < middle segment < apical segment and subepicardial < middle < subendocardial layer (p < 0.05), and the degree of decrease also showed a regular pattern of epicardial layer < middle layer < subendocardial layer while the difference was not significant (p > 0.05). After chemotherapy, maximum flow rate in early mitral relaxation/left atrial systolic maximum flow rate (E/A) and left atrial volume index of each group were in the normal range, and the values of LASr, LAScd, and LASct slightly increased in the second cycle and decreased significantly in the fourth cycle after chemotherapy, reaching the lowest level; LASr and LAScd were positively correlated with GLS.ConclusionLVGLS is a more sensitive and earlier indicator to predict CTRCD compared with conventional echocardiography-related parameters and serological markers, and GLS of each myocardial layer showed a certain regularity. Left atrial strain can be used for early monitoring of cardiotoxicity in children with lymphoma after chemotherapy.https://www.frontiersin.org/articles/10.3389/fped.2023.1163664/fullspeckle-tracking echocardiographycancer treatment-related cardiac dysfunctionlongitudinal strainchildrenleft atrial strain |
| spellingShingle | Jiaqi Chen Chunyue Cheng Li Fan Xiaochuan Xu Jing Chen Yang Feng Yi Tang Chunjiang Yang Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma Frontiers in Pediatrics speckle-tracking echocardiography cancer treatment-related cardiac dysfunction longitudinal strain children left atrial strain |
| title | Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma |
| title_full | Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma |
| title_fullStr | Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma |
| title_full_unstemmed | Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma |
| title_short | Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma |
| title_sort | assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma |
| topic | speckle-tracking echocardiography cancer treatment-related cardiac dysfunction longitudinal strain children left atrial strain |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1163664/full |
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