Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis
Objectives: Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2018.1456463 |
| _version_ | 1819060647434911744 |
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| author | Xuemei Liu Tingting Zhai Ruixia Ma Congjuan Luo Huifang Wang Liqiu Liu |
| author_facet | Xuemei Liu Tingting Zhai Ruixia Ma Congjuan Luo Huifang Wang Liqiu Liu |
| author_sort | Xuemei Liu |
| collection | DOAJ |
| description | Objectives: Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly. Methods: Pubmed, Embase, the Cochrane library, CBM were searched for randomized controlled trials (RCTs) that assessed the efficiency of lowering serum uric acid therapy on the progression of CKD without language restriction. Summary estimates of weighted mean differences (WMDs) and relative risk (RR) were obtained by using random-effect or fixed-effect models. Sensitivity analyses were performed to identify the source of heterogeneity. Results: A total of 12 randomized controlled trials with 832 CKD participants were included in the analysis. Pooled estimate for eGFR was in favor of lowering serum uric acid therapy with a mean difference (MD) of 3.88 ml/min/1.73 m2, 95% CI 1.26–6.49 ml/min/1.73 m2, p = .004 and this was consistent with results for serum creatinine. The risk of worsening of kidney function or ESRD or death was significantly decreased in the treatment group compared to the control group (RR 0.39, 95% CI 0.28–0.52, p< .01). Conclusions: Uric acid-lowering therapy may be effective in retarding the progression of CKD. Further randomized controlled trials should be performed to confirm the effect of lowering serum uric acid therapy on the progression of CKD. |
| first_indexed | 2024-12-21T14:30:19Z |
| format | Article |
| id | doaj.art-921eeec077b54ee99a467043b4086c8c |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-21T14:30:19Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-921eeec077b54ee99a467043b4086c8c2022-12-21T19:00:31ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-0140128929710.1080/0886022X.2018.14564631456463Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysisXuemei Liu0Tingting Zhai1Ruixia Ma2Congjuan Luo3Huifang Wang4Liqiu Liu5The Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityObjectives: Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly. Methods: Pubmed, Embase, the Cochrane library, CBM were searched for randomized controlled trials (RCTs) that assessed the efficiency of lowering serum uric acid therapy on the progression of CKD without language restriction. Summary estimates of weighted mean differences (WMDs) and relative risk (RR) were obtained by using random-effect or fixed-effect models. Sensitivity analyses were performed to identify the source of heterogeneity. Results: A total of 12 randomized controlled trials with 832 CKD participants were included in the analysis. Pooled estimate for eGFR was in favor of lowering serum uric acid therapy with a mean difference (MD) of 3.88 ml/min/1.73 m2, 95% CI 1.26–6.49 ml/min/1.73 m2, p = .004 and this was consistent with results for serum creatinine. The risk of worsening of kidney function or ESRD or death was significantly decreased in the treatment group compared to the control group (RR 0.39, 95% CI 0.28–0.52, p< .01). Conclusions: Uric acid-lowering therapy may be effective in retarding the progression of CKD. Further randomized controlled trials should be performed to confirm the effect of lowering serum uric acid therapy on the progression of CKD.http://dx.doi.org/10.1080/0886022X.2018.1456463Uric acidchronic kidney diseaseuric acid-lowering therapyrandomized controlled trials |
| spellingShingle | Xuemei Liu Tingting Zhai Ruixia Ma Congjuan Luo Huifang Wang Liqiu Liu Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis Renal Failure Uric acid chronic kidney disease uric acid-lowering therapy randomized controlled trials |
| title | Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis |
| title_full | Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis |
| title_fullStr | Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis |
| title_full_unstemmed | Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis |
| title_short | Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis |
| title_sort | effects of uric acid lowering therapy on the progression of chronic kidney disease a systematic review and meta analysis |
| topic | Uric acid chronic kidney disease uric acid-lowering therapy randomized controlled trials |
| url | http://dx.doi.org/10.1080/0886022X.2018.1456463 |
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