Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors

Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors

Abstract Background Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We assessed the sensitivity of endometrial cancer cell lines to PARP inhibitors...

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Bibliographic Details
Main Authors: Charles-André Philip, Ido Laskov, Marie-Claude Beauchamp, Maud Marques, Oreekha Amin, Joanna Bitharas, Roy Kessous, Liron Kogan, Tahira Baloch, Walter H. Gotlieb, Amber Yasmeen
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Cancer
Subjects:
Endometrial cancer
PTEN
PI3K/mTOR pathway
PARP inhibitor
DNA repair pathway
RAD51
Online Access:http://link.springer.com/article/10.1186/s12885-017-3639-0

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