Predictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency department
Abstract Background The prognostic performance of soluble CD40L (sCD40L) for illness severity in infectious diseases is rarely reported. We investigated the ability of sCD40L combined with Acute Physiology and Chronic Health Evaluation II (APACHE II) score to evaluate mortality in septic patients in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12871-023-02381-w |
| _version_ | 1797349727892668416 |
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| author | Long Yang Jun Yang Xiangqun Zhang Xinghua Ye Yugeng Liu Bing Wei Junyu Wang |
| author_facet | Long Yang Jun Yang Xiangqun Zhang Xinghua Ye Yugeng Liu Bing Wei Junyu Wang |
| author_sort | Long Yang |
| collection | DOAJ |
| description | Abstract Background The prognostic performance of soluble CD40L (sCD40L) for illness severity in infectious diseases is rarely reported. We investigated the ability of sCD40L combined with Acute Physiology and Chronic Health Evaluation II (APACHE II) score to evaluate mortality in septic patients in the emergency department(ED). Methods We enrolled 222 septic patients in the ED of Beijing Chao-Yang Hospital from October 2020 to April 2021. Their serum sCD40L, PCT, lactate (Lac), Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score were used to predict the prognosis of septic patients in terms of 28-day mortality. Serum sCD40L was detected by Human XL Cytokine Luminex. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to assess the prognostic value of the variables. Results One hundred ninety-five patients met the inclusion criteria, divided into survival group (55 cases) and non-survival group (140 cases). sCD40L, PCT, Lac, SOFA and APACHE II score were found to independently predict 28-day mortality (P < 0.05). The AUC values of sCD40L, PCT, Lac, SOFA and APACHE II score were 0.662,0.727,0.704, 0.719 and 0.716, respectively. There was no difference in the diagnostic value of sCD40L compared with the PCT, Lac, SOFA score or APACHE II score (Z 1 = 1.19, P = 0.234; Z 2 = 0.77, P = 0.441; Z 3 = 1.05, P = 0.294; Z 4 = 0.97, P = 0.332). However, the combined evaluation of sCD40L + APACHE II (AUC:0.772, Z = 2.10, P = 0.036) was much better than sCD40L alone in predicting 28-day mortality. Conclusion The predictive value of sCD40L + APACHE II is better than sCD40L alone for 28-day mortality. sCD40L combined with APACHE II score is valuable for predicting 28-day mortality in elderly patients with sepsis. |
| first_indexed | 2024-03-08T12:34:34Z |
| format | Article |
| id | doaj.art-9220d7f8eb4842d6a800f2035cb09dd5 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-03-08T12:34:34Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-9220d7f8eb4842d6a800f2035cb09dd52024-01-21T12:32:51ZengBMCBMC Anesthesiology1471-22532024-01-012411910.1186/s12871-023-02381-wPredictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency departmentLong Yang0Jun Yang1Xiangqun Zhang2Xinghua Ye3Yugeng Liu4Bing Wei5Junyu Wang6Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute Infection, Capital Medical UniversityEmergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute Infection, Capital Medical UniversityEmergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute Infection, Capital Medical UniversityEmergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute Infection, Capital Medical UniversityEmergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute Infection, Capital Medical UniversityEmergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute Infection, Capital Medical UniversityEmergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation. Clinical Center for Medicine in Acute Infection, Capital Medical UniversityAbstract Background The prognostic performance of soluble CD40L (sCD40L) for illness severity in infectious diseases is rarely reported. We investigated the ability of sCD40L combined with Acute Physiology and Chronic Health Evaluation II (APACHE II) score to evaluate mortality in septic patients in the emergency department(ED). Methods We enrolled 222 septic patients in the ED of Beijing Chao-Yang Hospital from October 2020 to April 2021. Their serum sCD40L, PCT, lactate (Lac), Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score were used to predict the prognosis of septic patients in terms of 28-day mortality. Serum sCD40L was detected by Human XL Cytokine Luminex. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to assess the prognostic value of the variables. Results One hundred ninety-five patients met the inclusion criteria, divided into survival group (55 cases) and non-survival group (140 cases). sCD40L, PCT, Lac, SOFA and APACHE II score were found to independently predict 28-day mortality (P < 0.05). The AUC values of sCD40L, PCT, Lac, SOFA and APACHE II score were 0.662,0.727,0.704, 0.719 and 0.716, respectively. There was no difference in the diagnostic value of sCD40L compared with the PCT, Lac, SOFA score or APACHE II score (Z 1 = 1.19, P = 0.234; Z 2 = 0.77, P = 0.441; Z 3 = 1.05, P = 0.294; Z 4 = 0.97, P = 0.332). However, the combined evaluation of sCD40L + APACHE II (AUC:0.772, Z = 2.10, P = 0.036) was much better than sCD40L alone in predicting 28-day mortality. Conclusion The predictive value of sCD40L + APACHE II is better than sCD40L alone for 28-day mortality. sCD40L combined with APACHE II score is valuable for predicting 28-day mortality in elderly patients with sepsis.https://doi.org/10.1186/s12871-023-02381-wsCD40LAPACHE II score28-day mortality |
| spellingShingle | Long Yang Jun Yang Xiangqun Zhang Xinghua Ye Yugeng Liu Bing Wei Junyu Wang Predictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency department BMC Anesthesiology sCD40L APACHE II score 28-day mortality |
| title | Predictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency department |
| title_full | Predictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency department |
| title_fullStr | Predictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency department |
| title_full_unstemmed | Predictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency department |
| title_short | Predictive value of soluble CD40L combined with APACHE II score in elderly patients with sepsis in the emergency department |
| title_sort | predictive value of soluble cd40l combined with apache ii score in elderly patients with sepsis in the emergency department |
| topic | sCD40L APACHE II score 28-day mortality |
| url | https://doi.org/10.1186/s12871-023-02381-w |
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