Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rash
Abstract Hyper‐IgE (HIES) is a rare, primary immunodeficiency characterised by eczema, recurrent staphylococcal infections, pneumonia, increased serum IgE and eosinophilia. We present the case of an 11‐year‐old girl presenting to dermatology with an acneiform facial rash and associated bacterial lym...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-02-01
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| Series: | Skin Health and Disease |
| Online Access: | https://doi.org/10.1002/ski2.297 |
| _version_ | 1797336244241301504 |
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| author | Berbie Byrne Tom Hefferon Rob Harrington Marion Leahy Annette Murphy |
| author_facet | Berbie Byrne Tom Hefferon Rob Harrington Marion Leahy Annette Murphy |
| author_sort | Berbie Byrne |
| collection | DOAJ |
| description | Abstract Hyper‐IgE (HIES) is a rare, primary immunodeficiency characterised by eczema, recurrent staphylococcal infections, pneumonia, increased serum IgE and eosinophilia. We present the case of an 11‐year‐old girl presenting to dermatology with an acneiform facial rash and associated bacterial lymphadenitis. History was significant for otitis media, primary tooth retention, low impact wrist fracture, infantile acne and an absence of eczema or pneumonia. Investigations demonstrated mildly elevated IgE, normal eosinophils but positivity for a STAT3 gene mutation—thus representing a case of HIES presenting as an acneiform facial rash with absence of other primary immunological features. |
| first_indexed | 2024-03-08T08:51:26Z |
| format | Article |
| id | doaj.art-92220662b68640b8bb551ba51f172193 |
| institution | Directory Open Access Journal |
| issn | 2690-442X |
| language | English |
| last_indexed | 2024-03-08T08:51:26Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Skin Health and Disease |
| spelling | doaj.art-92220662b68640b8bb551ba51f1721932024-02-01T09:32:21ZengWileySkin Health and Disease2690-442X2024-02-0141n/an/a10.1002/ski2.297Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rashBerbie Byrne0Tom Hefferon1Rob Harrington2Marion Leahy3Annette Murphy4Department of Dermatology University Hospital Galway Galway IrelandDepartment of Dermatology University Hospital Galway Galway IrelandDepartment of Dermatology University Hospital Galway Galway IrelandDepartment of Dermatology University Hospital Galway Galway IrelandDepartment of Dermatology University Hospital Galway Galway IrelandAbstract Hyper‐IgE (HIES) is a rare, primary immunodeficiency characterised by eczema, recurrent staphylococcal infections, pneumonia, increased serum IgE and eosinophilia. We present the case of an 11‐year‐old girl presenting to dermatology with an acneiform facial rash and associated bacterial lymphadenitis. History was significant for otitis media, primary tooth retention, low impact wrist fracture, infantile acne and an absence of eczema or pneumonia. Investigations demonstrated mildly elevated IgE, normal eosinophils but positivity for a STAT3 gene mutation—thus representing a case of HIES presenting as an acneiform facial rash with absence of other primary immunological features.https://doi.org/10.1002/ski2.297 |
| spellingShingle | Berbie Byrne Tom Hefferon Rob Harrington Marion Leahy Annette Murphy Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rash Skin Health and Disease |
| title | Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rash |
| title_full | Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rash |
| title_fullStr | Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rash |
| title_full_unstemmed | Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rash |
| title_short | Hyper‐IgE syndrome in an 11 year old female presenting with acneiform rash |
| title_sort | hyper ige syndrome in an 11 year old female presenting with acneiform rash |
| url | https://doi.org/10.1002/ski2.297 |
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