Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis
<p>Abstract</p> <p>Background</p> <p>Antimicrobial catheters have been utilized to reduce risk of catheter colonization and infection. We aimed to determine if there is a greater than expected risk of microorganism-specific colonization associated with the use of antimi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-12-01
|
| Series: | Antimicrobial Resistance and Infection Control |
| Subjects: | |
| Online Access: | http://www.aricjournal.com/content/1/1/40 |
| _version_ | 1818755353728253952 |
|---|---|
| author | Novikov Aleksey Lam Manuel Y Mermel Leonard A Casey Anna L Elliott Tom S Nightingale Peter |
| author_facet | Novikov Aleksey Lam Manuel Y Mermel Leonard A Casey Anna L Elliott Tom S Nightingale Peter |
| author_sort | Novikov Aleksey |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Antimicrobial catheters have been utilized to reduce risk of catheter colonization and infection. We aimed to determine if there is a greater than expected risk of microorganism-specific colonization associated with the use of antimicrobial central venous catheters (CVCs).</p> <p>Methods</p> <p>We performed a meta-analysis of 21 randomized, controlled trials comparing the incidence of specific bacterial and fungal species colonizing antimicrobial CVCs and standard CVCs in hospitalized patients.</p> <p>Results</p> <p>The proportion of all colonized minocycline-rifampin CVCs found to harbor <it>Candida</it> species was greater than the proportion of all colonized standard CVCs found to have <it>Candida</it>. In comparison, the proportion of colonized chlorhexidine-silver sulfadiazine CVCs specifically colonized with <it>Acinetobacter</it> species or diphtheroids was less than the proportion of similarly colonized standard CVCs. No such differences were found with CVCs colonized with staphylococci.</p> <p>Conclusion</p> <p>Commercially-available antimicrobial CVCs in clinical use may become colonized with distinct microbial flora probably related to their antimicrobial spectrum of activity. Some of these antimicrobial CVCs may therefore have limited additional benefit or more obvious advantages compared to standard CVCs for specific microbial pathogens. The choice of an antimicrobial CVC may be influenced by a number of clinical factors, including a previous history of colonization or infection with <it>Acinetobacter</it>, diphtheroids, or <it>Candida</it> species.</p> |
| first_indexed | 2024-12-18T05:37:48Z |
| format | Article |
| id | doaj.art-9222c788eaad449a865b823b8d992cd9 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-12-18T05:37:48Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-9222c788eaad449a865b823b8d992cd92022-12-21T21:19:15ZengBMCAntimicrobial Resistance and Infection Control2047-29942012-12-01114010.1186/2047-2994-1-40Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysisNovikov AlekseyLam Manuel YMermel Leonard ACasey Anna LElliott Tom SNightingale Peter<p>Abstract</p> <p>Background</p> <p>Antimicrobial catheters have been utilized to reduce risk of catheter colonization and infection. We aimed to determine if there is a greater than expected risk of microorganism-specific colonization associated with the use of antimicrobial central venous catheters (CVCs).</p> <p>Methods</p> <p>We performed a meta-analysis of 21 randomized, controlled trials comparing the incidence of specific bacterial and fungal species colonizing antimicrobial CVCs and standard CVCs in hospitalized patients.</p> <p>Results</p> <p>The proportion of all colonized minocycline-rifampin CVCs found to harbor <it>Candida</it> species was greater than the proportion of all colonized standard CVCs found to have <it>Candida</it>. In comparison, the proportion of colonized chlorhexidine-silver sulfadiazine CVCs specifically colonized with <it>Acinetobacter</it> species or diphtheroids was less than the proportion of similarly colonized standard CVCs. No such differences were found with CVCs colonized with staphylococci.</p> <p>Conclusion</p> <p>Commercially-available antimicrobial CVCs in clinical use may become colonized with distinct microbial flora probably related to their antimicrobial spectrum of activity. Some of these antimicrobial CVCs may therefore have limited additional benefit or more obvious advantages compared to standard CVCs for specific microbial pathogens. The choice of an antimicrobial CVC may be influenced by a number of clinical factors, including a previous history of colonization or infection with <it>Acinetobacter</it>, diphtheroids, or <it>Candida</it> species.</p>http://www.aricjournal.com/content/1/1/40Central venous catheterCatheter colonizationCatheter-related bloodstream infectionCentral line-associated bloodstream infectionBacteremiaAntimicrobial catheter |
| spellingShingle | Novikov Aleksey Lam Manuel Y Mermel Leonard A Casey Anna L Elliott Tom S Nightingale Peter Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis Antimicrobial Resistance and Infection Control Central venous catheter Catheter colonization Catheter-related bloodstream infection Central line-associated bloodstream infection Bacteremia Antimicrobial catheter |
| title | Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis |
| title_full | Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis |
| title_fullStr | Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis |
| title_full_unstemmed | Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis |
| title_short | Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis |
| title_sort | impact of catheter antimicrobial coating on species specific risk of catheter colonization a meta analysis |
| topic | Central venous catheter Catheter colonization Catheter-related bloodstream infection Central line-associated bloodstream infection Bacteremia Antimicrobial catheter |
| url | http://www.aricjournal.com/content/1/1/40 |
| work_keys_str_mv | AT novikovaleksey impactofcatheterantimicrobialcoatingonspeciesspecificriskofcathetercolonizationametaanalysis AT lammanuely impactofcatheterantimicrobialcoatingonspeciesspecificriskofcathetercolonizationametaanalysis AT mermelleonarda impactofcatheterantimicrobialcoatingonspeciesspecificriskofcathetercolonizationametaanalysis AT caseyannal impactofcatheterantimicrobialcoatingonspeciesspecificriskofcathetercolonizationametaanalysis AT elliotttoms impactofcatheterantimicrobialcoatingonspeciesspecificriskofcathetercolonizationametaanalysis AT nightingalepeter impactofcatheterantimicrobialcoatingonspeciesspecificriskofcathetercolonizationametaanalysis |