MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
Abstract MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-021-01111-4 |
| _version_ | 1818444079990571008 |
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| author | Seyed Esmaeil Ahmadi Samira Rahimi Bahman Zarandi Rouzbeh Chegeni Majid Safa |
| author_facet | Seyed Esmaeil Ahmadi Samira Rahimi Bahman Zarandi Rouzbeh Chegeni Majid Safa |
| author_sort | Seyed Esmaeil Ahmadi |
| collection | DOAJ |
| description | Abstract MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies. |
| first_indexed | 2024-12-14T19:10:14Z |
| format | Article |
| id | doaj.art-9225a1d6c9c74a6797548088c0548e98 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-14T19:10:14Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-9225a1d6c9c74a6797548088c0548e982022-12-21T22:50:45ZengBMCJournal of Hematology & Oncology1756-87222021-08-0114114910.1186/s13045-021-01111-4MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignanciesSeyed Esmaeil Ahmadi0Samira Rahimi1Bahman Zarandi2Rouzbeh Chegeni3Majid Safa4Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical SciencesDepartment of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical SciencesDepartment of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical SciencesMedical Laboratory Sciences Program, College of Health and Human Sciences, Northern Illinois UniversityDepartment of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical SciencesAbstract MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.https://doi.org/10.1186/s13045-021-01111-4MYCOncogeneRegulationCell cycleApoptosisDNA damage response |
| spellingShingle | Seyed Esmaeil Ahmadi Samira Rahimi Bahman Zarandi Rouzbeh Chegeni Majid Safa MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies Journal of Hematology & Oncology MYC Oncogene Regulation Cell cycle Apoptosis DNA damage response |
| title | MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies |
| title_full | MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies |
| title_fullStr | MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies |
| title_full_unstemmed | MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies |
| title_short | MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies |
| title_sort | myc a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies |
| topic | MYC Oncogene Regulation Cell cycle Apoptosis DNA damage response |
| url | https://doi.org/10.1186/s13045-021-01111-4 |
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