Fibres and Colorectal Cancer: Clinical and Molecular Evidence
Colorectal cancer (CRC) is one of the leading causes of mortality for cancer in industrialized countries. The link between diet and CRC is well-known, and presumably CRC is the type of cancer which is most influenced by dietary habits. In Western countries, an inadequate dietary intake of fibers is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13501 |
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| author | Francesca Celiberto Adriana Aloisio Bruna Girardi Maria Pricci Andrea Iannone Francesco Russo Giuseppe Riezzo Benedetta D’Attoma Enzo Ierardi Giuseppe Losurdo Alfredo Di Leo |
| author_facet | Francesca Celiberto Adriana Aloisio Bruna Girardi Maria Pricci Andrea Iannone Francesco Russo Giuseppe Riezzo Benedetta D’Attoma Enzo Ierardi Giuseppe Losurdo Alfredo Di Leo |
| author_sort | Francesca Celiberto |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the leading causes of mortality for cancer in industrialized countries. The link between diet and CRC is well-known, and presumably CRC is the type of cancer which is most influenced by dietary habits. In Western countries, an inadequate dietary intake of fibers is endemic, and this could be a driving factor in the increase of CRC incidence. Indeed, several epidemiologic studies have elucidated an inverse relationship between daily fiber intake and risk of CRC. Long-term prognosis in CRC survivors is also dependent on dietary fibers. Several pathogenetic mechanisms may be hypothesized. Fibers may interfere with the metabolism of bile acids, which may promote colon carcinogenesis. Further, fibers are often contained in vegetables which, in turn, contain large amounts of antioxidant agents like resveratrol, polyphenols, or phytoestrogens. Moreover, fibers can be digested by commensal flora, thus producing compounds such as butyrate, which exerts an antiproliferative effect. Finally, fibers may modulate gut microbiota, whose composition has shown to be associated with CRC onset. In this regard, dietary interventions based on high-fiber-containing diets are ongoing to prevent CRC development, especially in patients with high potential for this type of tumor. Despite the fact that outcomes are preliminary, encouraging results have been observed. |
| first_indexed | 2024-03-10T23:20:39Z |
| format | Article |
| id | doaj.art-9226427daf8740d6b7070648063f1b0e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:20:39Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9226427daf8740d6b7070648063f1b0e2023-11-19T08:18:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171350110.3390/ijms241713501Fibres and Colorectal Cancer: Clinical and Molecular EvidenceFrancesca Celiberto0Adriana Aloisio1Bruna Girardi2Maria Pricci3Andrea Iannone4Francesco Russo5Giuseppe Riezzo6Benedetta D’Attoma7Enzo Ierardi8Giuseppe Losurdo9Alfredo Di Leo10Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalyTHD s.p.a., 42015 Correggio, ItalyTHD s.p.a., 42015 Correggio, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalyColorectal cancer (CRC) is one of the leading causes of mortality for cancer in industrialized countries. The link between diet and CRC is well-known, and presumably CRC is the type of cancer which is most influenced by dietary habits. In Western countries, an inadequate dietary intake of fibers is endemic, and this could be a driving factor in the increase of CRC incidence. Indeed, several epidemiologic studies have elucidated an inverse relationship between daily fiber intake and risk of CRC. Long-term prognosis in CRC survivors is also dependent on dietary fibers. Several pathogenetic mechanisms may be hypothesized. Fibers may interfere with the metabolism of bile acids, which may promote colon carcinogenesis. Further, fibers are often contained in vegetables which, in turn, contain large amounts of antioxidant agents like resveratrol, polyphenols, or phytoestrogens. Moreover, fibers can be digested by commensal flora, thus producing compounds such as butyrate, which exerts an antiproliferative effect. Finally, fibers may modulate gut microbiota, whose composition has shown to be associated with CRC onset. In this regard, dietary interventions based on high-fiber-containing diets are ongoing to prevent CRC development, especially in patients with high potential for this type of tumor. Despite the fact that outcomes are preliminary, encouraging results have been observed.https://www.mdpi.com/1422-0067/24/17/13501colorectal cancerfibersdietchemoprevention |
| spellingShingle | Francesca Celiberto Adriana Aloisio Bruna Girardi Maria Pricci Andrea Iannone Francesco Russo Giuseppe Riezzo Benedetta D’Attoma Enzo Ierardi Giuseppe Losurdo Alfredo Di Leo Fibres and Colorectal Cancer: Clinical and Molecular Evidence International Journal of Molecular Sciences colorectal cancer fibers diet chemoprevention |
| title | Fibres and Colorectal Cancer: Clinical and Molecular Evidence |
| title_full | Fibres and Colorectal Cancer: Clinical and Molecular Evidence |
| title_fullStr | Fibres and Colorectal Cancer: Clinical and Molecular Evidence |
| title_full_unstemmed | Fibres and Colorectal Cancer: Clinical and Molecular Evidence |
| title_short | Fibres and Colorectal Cancer: Clinical and Molecular Evidence |
| title_sort | fibres and colorectal cancer clinical and molecular evidence |
| topic | colorectal cancer fibers diet chemoprevention |
| url | https://www.mdpi.com/1422-0067/24/17/13501 |
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