Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-06-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/3/6/697/ |
| _version_ | 1828115906836824064 |
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| author | Andrea Bolognesi Massimo Bortolotti Manuela Pedrazzi Letizia Polito |
| author_facet | Andrea Bolognesi Massimo Bortolotti Manuela Pedrazzi Letizia Polito |
| author_sort | Andrea Bolognesi |
| collection | DOAJ |
| description | Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conjugates have been used in many experimental strategies against cancer cells, often showing great efficacy in clinical trials. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively utilized to construct anti-cancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells. This review summarizes saporin-S6-containing conjugates and their application in cancer therapy, considering in-vitro and in-vivo studies both in animal models and in clinical trials. The review is structured on the basis of the targeting of hematological versus solid tumors and on the antigen recognized on the cell surface. |
| first_indexed | 2024-04-11T12:48:44Z |
| format | Article |
| id | doaj.art-92268d3eff4940e29150795356e01e6e |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T12:48:44Z |
| publishDate | 2011-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-92268d3eff4940e29150795356e01e6e2022-12-22T04:23:17ZengMDPI AGToxins2072-66512011-06-013669772010.3390/toxins3060697Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer TherapyAndrea BolognesiMassimo BortolottiManuela PedrazziLetizia PolitoRibosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conjugates have been used in many experimental strategies against cancer cells, often showing great efficacy in clinical trials. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively utilized to construct anti-cancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells. This review summarizes saporin-S6-containing conjugates and their application in cancer therapy, considering in-vitro and in-vivo studies both in animal models and in clinical trials. The review is structured on the basis of the targeting of hematological versus solid tumors and on the antigen recognized on the cell surface.http://www.mdpi.com/2072-6651/3/6/697/saporin-S6plant toxinsimmunotoxinsimmunoconjugatesimmunotherapyanti-cancer therapy |
| spellingShingle | Andrea Bolognesi Massimo Bortolotti Manuela Pedrazzi Letizia Polito Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy Toxins saporin-S6 plant toxins immunotoxins immunoconjugates immunotherapy anti-cancer therapy |
| title | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
| title_full | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
| title_fullStr | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
| title_full_unstemmed | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
| title_short | Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy |
| title_sort | immunotoxins and other conjugates containing saporin s6 for cancer therapy |
| topic | saporin-S6 plant toxins immunotoxins immunoconjugates immunotherapy anti-cancer therapy |
| url | http://www.mdpi.com/2072-6651/3/6/697/ |
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