Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients
Abstract Colon adenocarcinoma (COAD) is a common malignant tumor, and the role of the protein PFKFB4 in glycolysis and pentose phosphate pathways is crucial. Researchers investigated the clinical significance of PFKFB4 in COAD by studying its expression in 79 tissue samples using immunohistochemistr...
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| Format: | Article |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43619-4 |
| _version_ | 1797371157208367104 |
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| author | Xiaojing Gu Xingchen Dai Yongli Huang Yuhuan Zhang Lintao Dong Chanchan Gao Fang Wang |
| author_facet | Xiaojing Gu Xingchen Dai Yongli Huang Yuhuan Zhang Lintao Dong Chanchan Gao Fang Wang |
| author_sort | Xiaojing Gu |
| collection | DOAJ |
| description | Abstract Colon adenocarcinoma (COAD) is a common malignant tumor, and the role of the protein PFKFB4 in glycolysis and pentose phosphate pathways is crucial. Researchers investigated the clinical significance of PFKFB4 in COAD by studying its expression in 79 tissue samples using immunohistochemistry. We found that PFKFB4 expression was significantly higher in COAD patients, particularly in the sigmoid colon. Interestingly, high PFKFB4 expression was associated with both improved overall survival (OS) and post-progression survival (PPS) in COAD patients. Further analysis revealed that genes associated with PFKFB4 were linked to various metabolic pathways, including amino acid biosynthesis, glycolysis, gluconeogenesis, glucose metabolism, and inflammatory response. PFKFB4 expression also showed correlations with the infiltration of different immune cell types in COAD patients, such as CD8+ T cells, CD4+ T cells, regulatory T cells (Tregs), macrophages, neutrophils, dendritic cells, active mast cells, and resting NK cells. Overall, the relationship between PFKFB4 expression and the prognosis of COAD is complex and diverse, possibly playing different roles at different stages of the disease. Moreover, its mechanism might involve interactions with various metabolic pathways and immune infiltration in the tumor microenvironment. These findings provide valuable insights into the potential role of PFKFB4 as a biomarker or therapeutic target in COAD. |
| first_indexed | 2024-03-08T18:15:43Z |
| format | Article |
| id | doaj.art-92279a219df740b7b6e6ce2dded5041d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T18:15:43Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-92279a219df740b7b6e6ce2dded5041d2023-12-31T12:10:58ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-43619-4Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patientsXiaojing Gu0Xingchen Dai1Yongli Huang2Yuhuan Zhang3Lintao Dong4Chanchan Gao5Fang Wang6Department of Gastroenterology, General Hospital, Ningxia Medical UniversityDepartment of Gastroenterology, General Hospital, Ningxia Medical UniversityKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Ningxia Medical UniversityDepartment of Gastroenterology, General Hospital, Ningxia Medical UniversityDepartment of Gastroenterology, General Hospital, Ningxia Medical UniversityDepartment of Oncology, Zhongda Hospital, Southeast UniversityDepartment of Gastroenterology, General Hospital, Ningxia Medical UniversityAbstract Colon adenocarcinoma (COAD) is a common malignant tumor, and the role of the protein PFKFB4 in glycolysis and pentose phosphate pathways is crucial. Researchers investigated the clinical significance of PFKFB4 in COAD by studying its expression in 79 tissue samples using immunohistochemistry. We found that PFKFB4 expression was significantly higher in COAD patients, particularly in the sigmoid colon. Interestingly, high PFKFB4 expression was associated with both improved overall survival (OS) and post-progression survival (PPS) in COAD patients. Further analysis revealed that genes associated with PFKFB4 were linked to various metabolic pathways, including amino acid biosynthesis, glycolysis, gluconeogenesis, glucose metabolism, and inflammatory response. PFKFB4 expression also showed correlations with the infiltration of different immune cell types in COAD patients, such as CD8+ T cells, CD4+ T cells, regulatory T cells (Tregs), macrophages, neutrophils, dendritic cells, active mast cells, and resting NK cells. Overall, the relationship between PFKFB4 expression and the prognosis of COAD is complex and diverse, possibly playing different roles at different stages of the disease. Moreover, its mechanism might involve interactions with various metabolic pathways and immune infiltration in the tumor microenvironment. These findings provide valuable insights into the potential role of PFKFB4 as a biomarker or therapeutic target in COAD.https://doi.org/10.1038/s41598-023-43619-4 |
| spellingShingle | Xiaojing Gu Xingchen Dai Yongli Huang Yuhuan Zhang Lintao Dong Chanchan Gao Fang Wang Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients Scientific Reports |
| title | Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients |
| title_full | Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients |
| title_fullStr | Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients |
| title_full_unstemmed | Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients |
| title_short | Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients |
| title_sort | differential roles of highly expressed pfkfb4 in colon adenocarcinoma patients |
| url | https://doi.org/10.1038/s41598-023-43619-4 |
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