Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context
Abstract Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, an...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | https://doi.org/10.1186/s43042-024-00485-7 |
| _version_ | 1797276487342096384 |
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| author | Md. Saddam Shamrat Kumar Paul Mohammad Ahsan Habib Md. Abrar Fahim Afsana Mimi Saiful Islam Bristi Paul Md Mostofa Uddin Helal |
| author_facet | Md. Saddam Shamrat Kumar Paul Mohammad Ahsan Habib Md. Abrar Fahim Afsana Mimi Saiful Islam Bristi Paul Md Mostofa Uddin Helal |
| author_sort | Md. Saddam |
| collection | DOAJ |
| description | Abstract Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis-inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning, and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, multiple sclerosis, diabetes. In this review, we addressed the genetic information and structural homology of BCL-2 family members. Further, we elucidate the pro-apoptotic and anti-apoptotic roles of the family members. This review highlights the most recent developments in the BCL-2 protein family and presents evidence that targeting this family proteins may have a positive impact on the treatment of medical problems that are still underserved. |
| first_indexed | 2024-03-07T15:28:53Z |
| format | Article |
| id | doaj.art-92291bc9da47422cb27b36f1b508e013 |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-03-07T15:28:53Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-92291bc9da47422cb27b36f1b508e0132024-03-05T16:31:54ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412024-01-0125112810.1186/s43042-024-00485-7Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic contextMd. Saddam0Shamrat Kumar Paul1Mohammad Ahsan Habib2Md. Abrar Fahim3Afsana Mimi4Saiful Islam5Bristi Paul6Md Mostofa Uddin Helal7Department of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Fisheries and Marine Bioscience, Faculty of Biological Science, Jashore University of Science and TechnologyState Key Laboratory of Sustainable Dryland Agriculture, Institute of Wheat Research, Shanxi Agricultural UniversityAbstract Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis-inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning, and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, multiple sclerosis, diabetes. In this review, we addressed the genetic information and structural homology of BCL-2 family members. Further, we elucidate the pro-apoptotic and anti-apoptotic roles of the family members. This review highlights the most recent developments in the BCL-2 protein family and presents evidence that targeting this family proteins may have a positive impact on the treatment of medical problems that are still underserved.https://doi.org/10.1186/s43042-024-00485-7BCL-2 family proteinBCL-2 domainsApoptosisCancerBiomarkersTherapeutic agents |
| spellingShingle | Md. Saddam Shamrat Kumar Paul Mohammad Ahsan Habib Md. Abrar Fahim Afsana Mimi Saiful Islam Bristi Paul Md Mostofa Uddin Helal Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context Egyptian Journal of Medical Human Genetics BCL-2 family protein BCL-2 domains Apoptosis Cancer Biomarkers Therapeutic agents |
| title | Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context |
| title_full | Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context |
| title_fullStr | Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context |
| title_full_unstemmed | Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context |
| title_short | Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context |
| title_sort | emerging biomarkers and potential therapeutics of the bcl 2 protein family the apoptotic and anti apoptotic context |
| topic | BCL-2 family protein BCL-2 domains Apoptosis Cancer Biomarkers Therapeutic agents |
| url | https://doi.org/10.1186/s43042-024-00485-7 |
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