Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning
Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decrease...
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| Format: | Article |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2018.00435/full |
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| author | Scott Cocking Scott Cocking N. T. Cable N. T. Cable Mathew G. Wilson Mathew G. Wilson Daniel J. Green Daniel J. Green Dick H. J. Thijssen Dick H. J. Thijssen Helen Jones |
| author_facet | Scott Cocking Scott Cocking N. T. Cable N. T. Cable Mathew G. Wilson Mathew G. Wilson Daniel J. Green Daniel J. Green Dick H. J. Thijssen Dick H. J. Thijssen Helen Jones |
| author_sort | Scott Cocking |
| collection | DOAJ |
| description | Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise.Methods: Eighteen healthy, recreationally trained, male participants (mean ±SD: age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise. Brachial artery diameter and blood flow were assessed every 5-min throughout the 30-min submaximal exercise using high resolution ultrasonography. Pre- and post-exercise vascular function was measured using flow-mediated dilation (FMD).Results: IPC resulted in enlarged brachial artery diameter during exercise [0.016 cm (0.003–0.03 cm), P = 0.015] compared to REMOTE IPC, but blood flow during exercise was similar between conditions (P > 0.05). Blood flow (l/min) increased throughout exercise (time: P < 0.005), but there was no main effect of condition (P = 0.29) or condition ∗ time interaction (P = 0.83). Post-exercise FMD was similar between conditions (P > 0.05).Conclusion: Our data show that local (but not remote) IPC, performed as a strategy prior to exercise, enhanced exercise-induced conduit artery diameter dilation, but these changes do not translate into increased blood flow during exercise nor impact post-exercise vascular function. |
| first_indexed | 2024-04-12T21:24:46Z |
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| id | doaj.art-922b739b94514cd7939e6f4569d77d5b |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T21:24:46Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-922b739b94514cd7939e6f4569d77d5b2022-12-22T03:16:12ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-04-01910.3389/fphys.2018.00435352426Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic PreconditioningScott Cocking0Scott Cocking1N. T. Cable2N. T. Cable3Mathew G. Wilson4Mathew G. Wilson5Daniel J. Green6Daniel J. Green7Dick H. J. Thijssen8Dick H. J. Thijssen9Helen Jones10Athlete Health and Performance Research Centre, Aspetar Orthopaedic and Sports Medicine Hospital, Doha, QatarResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United KingdomDepartment of Sport Science, Aspire Academy, Doha, QatarSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomAthlete Health and Performance Research Centre, Aspetar Orthopaedic and Sports Medicine Hospital, Doha, QatarResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United KingdomResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United KingdomSport and Exercise Science, School of Human Sciences, Faculty of Science, The University of Western Australia, Crawley, WA, AustraliaResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United KingdomDepartment of Physiology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, NetherlandsResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United KingdomIntroduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise.Methods: Eighteen healthy, recreationally trained, male participants (mean ±SD: age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise. Brachial artery diameter and blood flow were assessed every 5-min throughout the 30-min submaximal exercise using high resolution ultrasonography. Pre- and post-exercise vascular function was measured using flow-mediated dilation (FMD).Results: IPC resulted in enlarged brachial artery diameter during exercise [0.016 cm (0.003–0.03 cm), P = 0.015] compared to REMOTE IPC, but blood flow during exercise was similar between conditions (P > 0.05). Blood flow (l/min) increased throughout exercise (time: P < 0.005), but there was no main effect of condition (P = 0.29) or condition ∗ time interaction (P = 0.83). Post-exercise FMD was similar between conditions (P > 0.05).Conclusion: Our data show that local (but not remote) IPC, performed as a strategy prior to exercise, enhanced exercise-induced conduit artery diameter dilation, but these changes do not translate into increased blood flow during exercise nor impact post-exercise vascular function.http://journal.frontiersin.org/article/10.3389/fphys.2018.00435/fullischemic preconditioningcardiovascularendothelial functionhandgrip exerciseblood flow |
| spellingShingle | Scott Cocking Scott Cocking N. T. Cable N. T. Cable Mathew G. Wilson Mathew G. Wilson Daniel J. Green Daniel J. Green Dick H. J. Thijssen Dick H. J. Thijssen Helen Jones Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning Frontiers in Physiology ischemic preconditioning cardiovascular endothelial function handgrip exercise blood flow |
| title | Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning |
| title_full | Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning |
| title_fullStr | Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning |
| title_full_unstemmed | Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning |
| title_short | Conduit Artery Diameter During Exercise Is Enhanced After Local, but Not Remote, Ischemic Preconditioning |
| title_sort | conduit artery diameter during exercise is enhanced after local but not remote ischemic preconditioning |
| topic | ischemic preconditioning cardiovascular endothelial function handgrip exercise blood flow |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2018.00435/full |
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