Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies
Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanos...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-02-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/487002 |
| _version_ | 1818440243829800960 |
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| author | Girish Gulab Meshram Neeraj Kaur Kanwaljeet Singh Hura |
| author_facet | Girish Gulab Meshram Neeraj Kaur Kanwaljeet Singh Hura |
| author_sort | Girish Gulab Meshram |
| collection | DOAJ |
| description | Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Treatment of GCMN has conventionally been surgical. However, the role of NRAS inhibitors and inactivation of nevus tissue by high hydrostatic pressure are being explored. We present a case of a 1-day-old neonate born with GCMN, along with a review of the literature. |
| first_indexed | 2024-12-14T18:09:16Z |
| format | Article |
| id | doaj.art-922b8c086d0c418c849a305284796164 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-14T18:09:16Z |
| publishDate | 2018-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-922b8c086d0c418c849a3052847961642022-12-21T22:52:18ZengKarger PublishersCase Reports in Dermatology1662-65672018-02-01101242810.1159/000487002487002Giant Congenital Melanocytic Nevi: An Update and Emerging TherapiesGirish Gulab MeshramNeeraj KaurKanwaljeet Singh HuraGiant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Treatment of GCMN has conventionally been surgical. However, the role of NRAS inhibitors and inactivation of nevus tissue by high hydrostatic pressure are being explored. We present a case of a 1-day-old neonate born with GCMN, along with a review of the literature.https://www.karger.com/Article/FullText/487002Giant congenital melanocytic neviNeurocutaneous melanosisMalignant melanoma |
| spellingShingle | Girish Gulab Meshram Neeraj Kaur Kanwaljeet Singh Hura Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies Case Reports in Dermatology Giant congenital melanocytic nevi Neurocutaneous melanosis Malignant melanoma |
| title | Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies |
| title_full | Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies |
| title_fullStr | Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies |
| title_full_unstemmed | Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies |
| title_short | Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies |
| title_sort | giant congenital melanocytic nevi an update and emerging therapies |
| topic | Giant congenital melanocytic nevi Neurocutaneous melanosis Malignant melanoma |
| url | https://www.karger.com/Article/FullText/487002 |
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