The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes
Background and aims: The purpose of this study was to investigate the effect of 8-weeks of high-intensity interval exercise with L-cysteine (LC) consumption on interleukin (IL)-13 and hydrogen peroxide of the heart tissue in young rats with type 2 diabetes (T2D). Methods: The statistical population...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahrekord University of Medical Sciences
2023-10-01
|
| Series: | Journal of Shahrekord University of Medical Sciences |
| Subjects: | |
| Online Access: | https://j.skums.ac.ir/PDF/jskums-25-172.pdf |
| _version_ | 1797386254329839616 |
|---|---|
| author | Mana Davoudi Akbar Nouri Habashi |
| author_facet | Mana Davoudi Akbar Nouri Habashi |
| author_sort | Mana Davoudi |
| collection | DOAJ |
| description | Background and aims: The purpose of this study was to investigate the effect of 8-weeks of high-intensity interval exercise with L-cysteine (LC) consumption on interleukin (IL)-13 and hydrogen peroxide of the heart tissue in young rats with type 2 diabetes (T2D). Methods: The statistical population of the present study consisted of young (4-month) rats with T2D. Ten rats were selected as a healthy group. Forty rats became diabetic. Diabetic rats were randomly divided into diabetes control, diabetics with exercise, diabetics with supplements, and diabetics with exercise and supplements. High-intensity interval exercises were performed 3 days a week for 8 weeks, and 500 μmol of LC were injected daily. Results: The healthy control group had lower IL-13 than the control group (P=0.001). There was no significant difference in IL-13 between other groups. Based on the results, the diabetes control group had a higher H2 O2 value than the healthy control group (P=0.001). A significant difference was found between the exercise group+LC consumption compared to the diabetes control group, and the H2 O2 levels in this group were less than the diabetic control group (P=0.001). The exercise (P=0.015) and LC (P=0.001) groups had a lower H2 O2 value than the diabetes control group. Eventually, the interval exercise group+LC was also lower than the periodic exercise group (P=0.02). Conclusion: High-intensity interval training, along with the use of LC, reduced hydrogen peroxide in the heart tissue, while it had no significant impact on IL-13. |
| first_indexed | 2024-03-08T22:07:40Z |
| format | Article |
| id | doaj.art-922d5f0e3abb4d41b9c95de18b6294b4 |
| institution | Directory Open Access Journal |
| issn | 2717-0071 |
| language | English |
| last_indexed | 2024-03-08T22:07:40Z |
| publishDate | 2023-10-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of Shahrekord University of Medical Sciences |
| spelling | doaj.art-922d5f0e3abb4d41b9c95de18b6294b42023-12-19T08:14:34ZengShahrekord University of Medical SciencesJournal of Shahrekord University of Medical Sciences2717-00712023-10-0125417217710.34172/jsums.796jskums-796The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetesMana Davoudi0Akbar Nouri Habashi1Department of Exercise Physiology, Faculty of Sport Science, Urmia University, Urmia, IranDepartment of Exercise Physiology, Faculty of Sport Science, Urmia University, Urmia, IranBackground and aims: The purpose of this study was to investigate the effect of 8-weeks of high-intensity interval exercise with L-cysteine (LC) consumption on interleukin (IL)-13 and hydrogen peroxide of the heart tissue in young rats with type 2 diabetes (T2D). Methods: The statistical population of the present study consisted of young (4-month) rats with T2D. Ten rats were selected as a healthy group. Forty rats became diabetic. Diabetic rats were randomly divided into diabetes control, diabetics with exercise, diabetics with supplements, and diabetics with exercise and supplements. High-intensity interval exercises were performed 3 days a week for 8 weeks, and 500 μmol of LC were injected daily. Results: The healthy control group had lower IL-13 than the control group (P=0.001). There was no significant difference in IL-13 between other groups. Based on the results, the diabetes control group had a higher H2 O2 value than the healthy control group (P=0.001). A significant difference was found between the exercise group+LC consumption compared to the diabetes control group, and the H2 O2 levels in this group were less than the diabetic control group (P=0.001). The exercise (P=0.015) and LC (P=0.001) groups had a lower H2 O2 value than the diabetes control group. Eventually, the interval exercise group+LC was also lower than the periodic exercise group (P=0.02). Conclusion: High-intensity interval training, along with the use of LC, reduced hydrogen peroxide in the heart tissue, while it had no significant impact on IL-13.https://j.skums.ac.ir/PDF/jskums-25-172.pdftype 2 diabetesil-13oxidative stressl-cysteine |
| spellingShingle | Mana Davoudi Akbar Nouri Habashi The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes Journal of Shahrekord University of Medical Sciences type 2 diabetes il-13 oxidative stress l-cysteine |
| title | The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes |
| title_full | The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes |
| title_fullStr | The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes |
| title_full_unstemmed | The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes |
| title_short | The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes |
| title_sort | effect of eight weeks of high intensity interval training with l cysteine consumption on interleukin 13 and oxidative stress of heart tissue in young rats with type 2 diabetes |
| topic | type 2 diabetes il-13 oxidative stress l-cysteine |
| url | https://j.skums.ac.ir/PDF/jskums-25-172.pdf |
| work_keys_str_mv | AT manadavoudi theeffectofeightweeksofhighintensityintervaltrainingwithlcysteineconsumptiononinterleukin13andoxidativestressofhearttissueinyoungratswithtype2diabetes AT akbarnourihabashi theeffectofeightweeksofhighintensityintervaltrainingwithlcysteineconsumptiononinterleukin13andoxidativestressofhearttissueinyoungratswithtype2diabetes AT manadavoudi effectofeightweeksofhighintensityintervaltrainingwithlcysteineconsumptiononinterleukin13andoxidativestressofhearttissueinyoungratswithtype2diabetes AT akbarnourihabashi effectofeightweeksofhighintensityintervaltrainingwithlcysteineconsumptiononinterleukin13andoxidativestressofhearttissueinyoungratswithtype2diabetes |