Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells

Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells

IntroductionDespite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains poor. There is thus a strong need for better identifying local immune dynamics and immune-suppressive pathways limiting T-cell mediated anti-tum...

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Bibliographic Details
Main Authors: Elena Tassi, Alice Bergamini, Jessica Wignall, Miriam Sant’Angelo, Emanuela Brunetto, Chiara Balestrieri, Miriam Redegalli, Alessia Potenza, Danilo Abbati, Francesco Manfredi, Maria Giulia Cangi, Gilda Magliacane, Fabiola Scalisi, Eliana Ruggiero, Maria Chiara Maffia, Federica Trippitelli, Emanuela Rabaiotti, Raffaella Cioffi, Luca Bocciolone, Giorgio Candotti, Massimo Candiani, Gianluca Taccagni, Birgit Schultes, Claudio Doglioni, Giorgia Mangili, Chiara Bonini
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
ovarian cancer
high grade serous ovarian cancer (HGSOC)
tumor-infiltrating lymphocytes (TIL)
tumor microenvironment (TME)
T-cell phenotype
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212444/full

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