Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles
In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity wi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Growing Science
2023-01-01
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| Series: | Current Chemistry Letters |
| Online Access: | http://www.growingscience.com/ccl/Vol12/ccl_2023_27.pdf |
| _version_ | 1797798483948732416 |
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| author | Iryna Myrko Taras Chaban Yuriy Horak olodymyr Ogurtsov Iryna Drapak Ihor Chaban Vasyl Matiychuk |
| author_facet | Iryna Myrko Taras Chaban Yuriy Horak olodymyr Ogurtsov Iryna Drapak Ihor Chaban Vasyl Matiychuk |
| author_sort | Iryna Myrko |
| collection | DOAJ |
| description | In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity. |
| first_indexed | 2024-03-13T04:04:24Z |
| format | Article |
| id | doaj.art-922e5aa7175f4cecb8eabf415d1a6cd3 |
| institution | Directory Open Access Journal |
| issn | 1927-7296 1927-730X |
| language | English |
| last_indexed | 2024-03-13T04:04:24Z |
| publishDate | 2023-01-01 |
| publisher | Growing Science |
| record_format | Article |
| series | Current Chemistry Letters |
| spelling | doaj.art-922e5aa7175f4cecb8eabf415d1a6cd32023-06-21T09:13:12ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2023-01-0112481382010.5267/j.ccl.2023.4.001Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazolesIryna MyrkoTaras ChabanYuriy Horakolodymyr OgurtsovIryna Drapak Ihor ChabanVasyl Matiychuk In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.http://www.growingscience.com/ccl/Vol12/ccl_2023_27.pdf |
| spellingShingle | Iryna Myrko Taras Chaban Yuriy Horak olodymyr Ogurtsov Iryna Drapak Ihor Chaban Vasyl Matiychuk Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles Current Chemistry Letters |
| title | Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles |
| title_full | Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles |
| title_fullStr | Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles |
| title_full_unstemmed | Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles |
| title_short | Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles |
| title_sort | anticancer properties of some triazolo 3 4 b 1 3 4 thiadiazoles |
| url | http://www.growingscience.com/ccl/Vol12/ccl_2023_27.pdf |
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