Early life insults as determinants of chronic obstructive pulmonary disease in adult life
Osman Savran,1 Charlotte Suppli Ulrik1,2 1Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark; 2Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Background: Early life events may predispose to the development of chronic lung disease in adulthood.Ai...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-02-01
|
| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/early-life-insults-as-determinants-of-chronic-obstructive-pulmonary-di-peer-reviewed-article-COPD |
| _version_ | 1818282503111180288 |
|---|---|
| author | Savran O Ulrik CS |
| author_facet | Savran O Ulrik CS |
| author_sort | Savran O |
| collection | DOAJ |
| description | Osman Savran,1 Charlotte Suppli Ulrik1,2 1Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark; 2Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Background: Early life events may predispose to the development of chronic lung disease in adulthood.Aim: To provide an update on current knowledge of early nongenetic origins of COPD.Materials and methods: Systematic literature review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Results: A total of 16 studies, comprising 69,365 individuals, met the predefined criteria and were included in the present review. Studies have shown that in utero tobacco exposure, low birth weight, preterm birth, and respiratory diseases, primarily asthma and pneumonia, in early childhood are associated with lung function impairment later in childhood, and by that predispose to subsequent development of COPD, although the causal association between childhood respiratory diseases and COPD has been questioned in one study. Environmental tobacco exposure has also been shown to have negative impact on lung function in childhood possibly leading to COPD in adulthood, although it is at present not possible to clearly distinguish between the impact of active and the environmental tobacco exposure on subsequent development of COPD.Conclusion: Tobacco exposure in utero and early life is a risk factor for subsequent development of COPD. Furthermore, low birth weight, lower respiratory tract infections and asthma, including wheezy bronchitis, in childhood also seem to be important determinants for later development of COPD. Early life insults may, therefore, be crucial to COPD development. Keywords: COPD, respiratory infections, obstructive lung disease, preterm birth, tobacco exposure, early life, secondhand smoke |
| first_indexed | 2024-12-13T00:22:03Z |
| format | Article |
| id | doaj.art-922fa3565e494d0eb589be72d42cf9d9 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-13T00:22:03Z |
| publishDate | 2018-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-922fa3565e494d0eb589be72d42cf9d92022-12-22T00:05:33ZengDove Medical PressInternational Journal of COPD1178-20052018-02-01Volume 1368369336950Early life insults as determinants of chronic obstructive pulmonary disease in adult lifeSavran OUlrik CSOsman Savran,1 Charlotte Suppli Ulrik1,2 1Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark; 2Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Background: Early life events may predispose to the development of chronic lung disease in adulthood.Aim: To provide an update on current knowledge of early nongenetic origins of COPD.Materials and methods: Systematic literature review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Results: A total of 16 studies, comprising 69,365 individuals, met the predefined criteria and were included in the present review. Studies have shown that in utero tobacco exposure, low birth weight, preterm birth, and respiratory diseases, primarily asthma and pneumonia, in early childhood are associated with lung function impairment later in childhood, and by that predispose to subsequent development of COPD, although the causal association between childhood respiratory diseases and COPD has been questioned in one study. Environmental tobacco exposure has also been shown to have negative impact on lung function in childhood possibly leading to COPD in adulthood, although it is at present not possible to clearly distinguish between the impact of active and the environmental tobacco exposure on subsequent development of COPD.Conclusion: Tobacco exposure in utero and early life is a risk factor for subsequent development of COPD. Furthermore, low birth weight, lower respiratory tract infections and asthma, including wheezy bronchitis, in childhood also seem to be important determinants for later development of COPD. Early life insults may, therefore, be crucial to COPD development. Keywords: COPD, respiratory infections, obstructive lung disease, preterm birth, tobacco exposure, early life, secondhand smoke https://www.dovepress.com/early-life-insults-as-determinants-of-chronic-obstructive-pulmonary-di-peer-reviewed-article-COPDCOPDrespiratory infectionsobstructive lung diseasepreterm birthtobacco exposureearly lifesecond hand smoke |
| spellingShingle | Savran O Ulrik CS Early life insults as determinants of chronic obstructive pulmonary disease in adult life International Journal of COPD COPD respiratory infections obstructive lung disease preterm birth tobacco exposure early life second hand smoke |
| title | Early life insults as determinants of chronic obstructive pulmonary disease in adult life |
| title_full | Early life insults as determinants of chronic obstructive pulmonary disease in adult life |
| title_fullStr | Early life insults as determinants of chronic obstructive pulmonary disease in adult life |
| title_full_unstemmed | Early life insults as determinants of chronic obstructive pulmonary disease in adult life |
| title_short | Early life insults as determinants of chronic obstructive pulmonary disease in adult life |
| title_sort | early life insults as determinants of chronic obstructive pulmonary disease in adult life |
| topic | COPD respiratory infections obstructive lung disease preterm birth tobacco exposure early life second hand smoke |
| url | https://www.dovepress.com/early-life-insults-as-determinants-of-chronic-obstructive-pulmonary-di-peer-reviewed-article-COPD |
| work_keys_str_mv | AT savrano earlylifeinsultsasdeterminantsofchronicobstructivepulmonarydiseaseinadultlife AT ulrikcs earlylifeinsultsasdeterminantsofchronicobstructivepulmonarydiseaseinadultlife |