Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease

Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease

Abstract Background With a growing number of loci associated with late-onset (sporadic) Alzheimer’s disease (AD), the polygenic contribution to AD is now well established. The development of polygenic risk score approaches have shown promising results for identifying individuals at higher risk of de...

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Bibliographic Details
Main Authors: Michael Vacher, Vincent Doré, Tenielle Porter, Lidija Milicic, Victor L. Villemagne, Pierrick Bourgeat, Sam C. Burnham, Timothy Cox, Colin L. Masters, Christopher C. Rowe, Jurgen Fripp, James D. Doecke, Simon M. Laws
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Genomics
Subjects:
Alzheimer’s disease
Polygenic hazard score
Brain atrophy
AD onset
Online Access:https://doi.org/10.1186/s12864-022-08617-2

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