RP-HPLC method development and validation for the quantification of Efonidipine hydrochloride in HME processed solid dispersions

RP-HPLC method development and validation for the quantification of Efonidipine hydrochloride in HME processed solid dispersions

Abstract Background Efonidipine hydrochloride (EFO) is a poorly water-soluble drug and, hence, has poor bioavailability. Solid dispersions (SDs) of EFO using Eudragit EPO were prepared using hot-melt extrusion (HME) for the first time. The current study aims at developing a simple RP-HPLC method to...

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Bibliographic Details
Main Authors: Ashish S. Rajput, Durgesh K. Jha, Sharda Gurram, Devanshi S. Shah, Purnima D. Amin
Format: Article
Language:English
Published: SpringerOpen 2020-10-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Efonidipine hydrochloride
Hot-melt extrusion
RP-HPLC
Micro-environmental pH
Solid dispersion
Online Access:http://link.springer.com/article/10.1186/s43094-020-00094-2

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http://link.springer.com/article/10.1186/s43094-020-00094-2

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