Human antimicrobial peptides in autoimmunity
Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-04-01
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| Series: | Autoimmunity |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08916934.2020.1711517 |
| _version_ | 1827817439644090368 |
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| author | Ekaterina S. Umnyakova Maria S. Zharkova Mikhail N. Berlov Olga V. Shamova Vladimir N. Kokryakov |
| author_facet | Ekaterina S. Umnyakova Maria S. Zharkova Mikhail N. Berlov Olga V. Shamova Vladimir N. Kokryakov |
| author_sort | Ekaterina S. Umnyakova |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are able to influence the activity of different innate and adaptive immunity components, thus, obviously, they also participate in autoimmune processes. In this review we discuss the nature of human AMPs and analyze their role in such autoimmune disorders like type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and sarcoidosis. These peptides were shown to have a “double-sided” influence on the autoimmune disease pathogenesis. Thus, described facts should be taken into account for the development of new pharmaceutical agents to cure patients with autoimmune disorders. These agents could derive from natural antimicrobial peptides that in some cases modulate immune response. For example, it was shown that human AMPs are able to modulate complement system dysregulation of which is known to be one of the most dangerous pathogenic factors during autoimmune processes. |
| first_indexed | 2024-03-12T00:34:17Z |
| format | Article |
| id | doaj.art-9231291b47e74bb6a6f18fb977d2242a |
| institution | Directory Open Access Journal |
| issn | 0891-6934 1607-842X |
| language | English |
| last_indexed | 2024-03-12T00:34:17Z |
| publishDate | 2020-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj.art-9231291b47e74bb6a6f18fb977d2242a2023-09-15T10:01:08ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2020-04-0153313714710.1080/08916934.2020.17115171711517Human antimicrobial peptides in autoimmunityEkaterina S. Umnyakova0Maria S. Zharkova1Mikhail N. Berlov2Olga V. Shamova3Vladimir N. Kokryakov4Institute of Experimental MedicineInstitute of Experimental MedicineInstitute of Experimental MedicineInstitute of Experimental MedicineInstitute of Experimental MedicineAntimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are able to influence the activity of different innate and adaptive immunity components, thus, obviously, they also participate in autoimmune processes. In this review we discuss the nature of human AMPs and analyze their role in such autoimmune disorders like type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and sarcoidosis. These peptides were shown to have a “double-sided” influence on the autoimmune disease pathogenesis. Thus, described facts should be taken into account for the development of new pharmaceutical agents to cure patients with autoimmune disorders. These agents could derive from natural antimicrobial peptides that in some cases modulate immune response. For example, it was shown that human AMPs are able to modulate complement system dysregulation of which is known to be one of the most dangerous pathogenic factors during autoimmune processes.http://dx.doi.org/10.1080/08916934.2020.1711517autoimmune diseasesantimicrobial peptidesα-defensinsβ-defensinscathelicidins |
| spellingShingle | Ekaterina S. Umnyakova Maria S. Zharkova Mikhail N. Berlov Olga V. Shamova Vladimir N. Kokryakov Human antimicrobial peptides in autoimmunity Autoimmunity autoimmune diseases antimicrobial peptides α-defensins β-defensins cathelicidins |
| title | Human antimicrobial peptides in autoimmunity |
| title_full | Human antimicrobial peptides in autoimmunity |
| title_fullStr | Human antimicrobial peptides in autoimmunity |
| title_full_unstemmed | Human antimicrobial peptides in autoimmunity |
| title_short | Human antimicrobial peptides in autoimmunity |
| title_sort | human antimicrobial peptides in autoimmunity |
| topic | autoimmune diseases antimicrobial peptides α-defensins β-defensins cathelicidins |
| url | http://dx.doi.org/10.1080/08916934.2020.1711517 |
| work_keys_str_mv | AT ekaterinasumnyakova humanantimicrobialpeptidesinautoimmunity AT mariaszharkova humanantimicrobialpeptidesinautoimmunity AT mikhailnberlov humanantimicrobialpeptidesinautoimmunity AT olgavshamova humanantimicrobialpeptidesinautoimmunity AT vladimirnkokryakov humanantimicrobialpeptidesinautoimmunity |