Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study
Background and Aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to deepen our understanding of the specific impact...
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MDPI AG
2024-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/1/86 |
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| author | Alfredo Caturano Raffaele Galiero Erica Vetrano Giulia Medicamento Maria Alfano Domenico Beccia Chiara Brin Sara Colantuoni Jessica Di Salvo Raffaella Epifani Riccardo Nevola Raffaele Marfella Celestino Sardu Carmine Coppola Ferdinando Scarano Paolo Maggi Cecilia Calabrese Pellegrino De Lucia Sposito Carolina Rescigno Costanza Sbreglia Fiorentino Fraganza Roberto Parrella Annamaria Romano Giosuele Calabria Benedetto Polverino Antonio Pagano Fabio Giuliano Numis Carolina Bologna Mariagrazia Nunziata Vincenzo Esposito Nicola Coppola Nicola Maturo Rodolfo Nasti Pierpaolo Di Micco Alessandro Perrella Luigi Elio Adinolfi Marina Di Domenico Marcellino Monda Vincenzo Russo Roberto Ruggiero Giovanni Docimo Luca Rinaldi Ferdinando Carlo Sasso |
| author_facet | Alfredo Caturano Raffaele Galiero Erica Vetrano Giulia Medicamento Maria Alfano Domenico Beccia Chiara Brin Sara Colantuoni Jessica Di Salvo Raffaella Epifani Riccardo Nevola Raffaele Marfella Celestino Sardu Carmine Coppola Ferdinando Scarano Paolo Maggi Cecilia Calabrese Pellegrino De Lucia Sposito Carolina Rescigno Costanza Sbreglia Fiorentino Fraganza Roberto Parrella Annamaria Romano Giosuele Calabria Benedetto Polverino Antonio Pagano Fabio Giuliano Numis Carolina Bologna Mariagrazia Nunziata Vincenzo Esposito Nicola Coppola Nicola Maturo Rodolfo Nasti Pierpaolo Di Micco Alessandro Perrella Luigi Elio Adinolfi Marina Di Domenico Marcellino Monda Vincenzo Russo Roberto Ruggiero Giovanni Docimo Luca Rinaldi Ferdinando Carlo Sasso |
| author_sort | Alfredo Caturano |
| collection | DOAJ |
| description | Background and Aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to deepen our understanding of the specific impact of acute kidney injury (AKI) on the in-hospital mortality in octogenarian patients with COVID-19. Methods: This is a prospective observational cohort study, which involved 23 COVID-19 hospital units in the Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. Only patients aged ≥80 years were deemed eligible for the study. Results: 197 patients were included in the study (median age 83.0 [82.0–87.0] years; 51.5% men), with a median duration of hospitalization of 15.0 [8.0–25.0] days. From the multivariable Cox regression analysis, after the application of Šidák correction, only the respiratory rate (HR 1.09, 95% CI: 1.04 to 1.14; <i>p</i> < 0.001) and AKI development (HR: 3.40, 95% CI: 1.80 to 6.40; <i>p</i> < 0.001) were independently associated with the primary outcome. Moreover, the Kaplan–Meier analysis showed a significantly different risk of in-hospital mortality between patients with and without AKI (log-rank: <0.0001). Conclusions: In our investigation, we identified a significant association between AKI and mortality rates among octogenarian patients admitted for COVID-19. These findings raise notable concerns and emphasize the imperative for vigilant monitoring of this demographic cohort. |
| first_indexed | 2024-03-08T10:44:30Z |
| format | Article |
| id | doaj.art-92312a49e260407bbc8fc6f083615e17 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-08T10:44:30Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-92312a49e260407bbc8fc6f083615e172024-01-26T17:20:47ZengMDPI AGLife2075-17292024-01-011418610.3390/life14010086Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA StudyAlfredo Caturano0Raffaele Galiero1Erica Vetrano2Giulia Medicamento3Maria Alfano4Domenico Beccia5Chiara Brin6Sara Colantuoni7Jessica Di Salvo8Raffaella Epifani9Riccardo Nevola10Raffaele Marfella11Celestino Sardu12Carmine Coppola13Ferdinando Scarano14Paolo Maggi15Cecilia Calabrese16Pellegrino De Lucia Sposito17Carolina Rescigno18Costanza Sbreglia19Fiorentino Fraganza20Roberto Parrella21Annamaria Romano22Giosuele Calabria23Benedetto Polverino24Antonio Pagano25Fabio Giuliano Numis26Carolina Bologna27Mariagrazia Nunziata28Vincenzo Esposito29Nicola Coppola30Nicola Maturo31Rodolfo Nasti32Pierpaolo Di Micco33Alessandro Perrella34Luigi Elio Adinolfi35Marina Di Domenico36Marcellino Monda37Vincenzo Russo38Roberto Ruggiero39Giovanni Docimo40Luca Rinaldi41Ferdinando Carlo Sasso42Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyHepatology Unit, Internal Medicine, Area Stabiese Hospital, 80053 Naples, ItalyCOVID Center “S. Anna e SS. Madonna della Neve” Hospital, 80042 Boscotrecase, ItalyU.O.C. Infectious and Tropical Diseases, S. Anna e S. Sebastiano Hospital, 81100 Caserta, ItalyU.O.C. Pneumologia Vanvitelli, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, AORN Ospedali dei Colli, Via Leonardo Bianchi, 80131 Naples, ItalyCOVID Center, Maddaloni Hospital, 80124 Maddaloni, ItalyU.O.C. Infectious Diseases and Neurology, Cotugno Hospital, 80131 Naples, ItalyU.O.C. Infectious Diseases of the Elderly, Cotugno Hospital, 80131 Naples, ItalyU.O.C. Anestesia and Intensive Care Unit, Cotugno Hospital, 80131 Naples, ItalyU.O.C. Respiratory Infectious Diseases, Cotugno Hospital, 80131 Naples, ItalyU.O.C. Pneumology, Moscati Hospital, 83100 Avellino, ItalyIXth Division of Infectious Diseases and Interventional Ultrasound, Cotugno Hospital, 80131 Naples, Italy“Giovanni da Procida” Hospital, 84126 Salerno, ItalyEmergency and Acceptance Unit, “Santa Maria delle Grazie” Hospital, 80078 Pozzuoli, ItalyEmergency and Acceptance Unit, “Santa Maria delle Grazie” Hospital, 80078 Pozzuoli, ItalyInternal Medicine Unit, Ospedale Del Mare, 80147 Naples, ItalyU.O.C. Internal Medicine, Moscati Hospital, 83100 Avellino, ItalyIVth Division of Immunodeficiency and Gender Infectious Diseases, Cotugno Hospital, 80131 Naples, ItalyCOVID Center, Department of Mental Health and Public Medicine, A.O.U. Vanvitelli, 80131 Naples, ItalyU.O.S.D. Infectious Diseases Emergency and Acceptance, Cotugno Hospital, 80131 Naples, ItalyEmergency Division, A.O.R.N. “Antonio Cardarelli”, 80131 Naples, ItalyDepartment of Internal Medicine, Fatebenefratelli Hospital of Naples, 80123 Naples, ItalyTask Force COVID-19 Regione Campania, 80131 Napoli, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80131 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Biology, College of Science and Technology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USADivision of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania “Luigi Vanvitelli”, 80131 Naples, ItalyUnit of Thyroid Surgery, Department of Medical and Advanced Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, 86100 Campobasso, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, ItalyBackground and Aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to deepen our understanding of the specific impact of acute kidney injury (AKI) on the in-hospital mortality in octogenarian patients with COVID-19. Methods: This is a prospective observational cohort study, which involved 23 COVID-19 hospital units in the Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. Only patients aged ≥80 years were deemed eligible for the study. Results: 197 patients were included in the study (median age 83.0 [82.0–87.0] years; 51.5% men), with a median duration of hospitalization of 15.0 [8.0–25.0] days. From the multivariable Cox regression analysis, after the application of Šidák correction, only the respiratory rate (HR 1.09, 95% CI: 1.04 to 1.14; <i>p</i> < 0.001) and AKI development (HR: 3.40, 95% CI: 1.80 to 6.40; <i>p</i> < 0.001) were independently associated with the primary outcome. Moreover, the Kaplan–Meier analysis showed a significantly different risk of in-hospital mortality between patients with and without AKI (log-rank: <0.0001). Conclusions: In our investigation, we identified a significant association between AKI and mortality rates among octogenarian patients admitted for COVID-19. These findings raise notable concerns and emphasize the imperative for vigilant monitoring of this demographic cohort.https://www.mdpi.com/2075-1729/14/1/86acute kidney injuryoctogenarianCOVID-19in-hospital mortalitySARS-CoV-2 |
| spellingShingle | Alfredo Caturano Raffaele Galiero Erica Vetrano Giulia Medicamento Maria Alfano Domenico Beccia Chiara Brin Sara Colantuoni Jessica Di Salvo Raffaella Epifani Riccardo Nevola Raffaele Marfella Celestino Sardu Carmine Coppola Ferdinando Scarano Paolo Maggi Cecilia Calabrese Pellegrino De Lucia Sposito Carolina Rescigno Costanza Sbreglia Fiorentino Fraganza Roberto Parrella Annamaria Romano Giosuele Calabria Benedetto Polverino Antonio Pagano Fabio Giuliano Numis Carolina Bologna Mariagrazia Nunziata Vincenzo Esposito Nicola Coppola Nicola Maturo Rodolfo Nasti Pierpaolo Di Micco Alessandro Perrella Luigi Elio Adinolfi Marina Di Domenico Marcellino Monda Vincenzo Russo Roberto Ruggiero Giovanni Docimo Luca Rinaldi Ferdinando Carlo Sasso Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study Life acute kidney injury octogenarian COVID-19 in-hospital mortality SARS-CoV-2 |
| title | Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study |
| title_full | Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study |
| title_fullStr | Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study |
| title_full_unstemmed | Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study |
| title_short | Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study |
| title_sort | impact of acute kidney injury on the covid 19 in hospital mortality in octogenarian patients insights from the covoca study |
| topic | acute kidney injury octogenarian COVID-19 in-hospital mortality SARS-CoV-2 |
| url | https://www.mdpi.com/2075-1729/14/1/86 |
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