Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational study
Abstract Purpose To study the optical coherence tomography (OCT) changes in eyes with acute central retinal artery occlusion (CRAO) of different severity and at different disease stages. Methods The study included acute CRAO cases of < 7 days duration, imaged on OCT at various time points. Based...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
|
| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40942-023-00475-8 |
| _version_ | 1797795593392750592 |
|---|---|
| author | Rubble Mangla Ramesh Venkatesh Rohini Sangoram Isha Acharya Yash Parmar Vishma Prabhu Naresh Kumar Yadav Jay Chhablani |
| author_facet | Rubble Mangla Ramesh Venkatesh Rohini Sangoram Isha Acharya Yash Parmar Vishma Prabhu Naresh Kumar Yadav Jay Chhablani |
| author_sort | Rubble Mangla |
| collection | DOAJ |
| description | Abstract Purpose To study the optical coherence tomography (OCT) changes in eyes with acute central retinal artery occlusion (CRAO) of different severity and at different disease stages. Methods The study included acute CRAO cases of < 7 days duration, imaged on OCT at various time points. Based on the OCT findings at presentation, cases were classified into three severity groups: mild, moderate, and severe. OCT scans were evaluated and classified into four-time intervals based on symptom duration. Results There were 39 eyes from 38 patients with acute CRAO who underwent 96 OCT scans. At presentation, the study had 11, 16, and 12 cases of mild, moderate, and severe CRAO, respectively. Middle retinal layer opacification was more common in mild CRAO cases, which caused inner retinal layer thinning over time. Moderate CRAO cases had total inner retinal layer opacification, which resulted in retinal thinning over time. Prominent middle limiting membrane (p-MLM) sign was seen in mild and moderate CRAO eyes while were not visualised in severe CRAO. This sign gradually faded out over time. Other OCT findings in higher grades of CRAO included inner retinal fluid, neurosensory detachment, internal limiting membrane detachment, hyperreflective foci, and posterior vitreous opacities. Regardless of the CRAO grade, the final end-point seen was inner retinal layer thinning over time. Conclusion OCT in CRAO is a useful for determining the severity of retinal ischemia, disease stage, tissue damage mechanism, and final visual outcome. More prospective studies analysing a larger number of cases at fixed time points will be required in the future. Trial Registration Trial Registration Number: Not applicable. |
| first_indexed | 2024-03-13T03:20:18Z |
| format | Article |
| id | doaj.art-9232e437cd1245e1ac51ba37483bde72 |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-03-13T03:20:18Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-9232e437cd1245e1ac51ba37483bde722023-06-25T11:24:18ZengBMCInternational Journal of Retina and Vitreous2056-99202023-06-019111010.1186/s40942-023-00475-8Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational studyRubble Mangla0Ramesh Venkatesh1Rohini Sangoram2Isha Acharya3Yash Parmar4Vishma Prabhu5Naresh Kumar Yadav6Jay Chhablani7Dept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousMedical Retina and Vitreoretinal Surgery, University of Pittsburgh School of MedicineAbstract Purpose To study the optical coherence tomography (OCT) changes in eyes with acute central retinal artery occlusion (CRAO) of different severity and at different disease stages. Methods The study included acute CRAO cases of < 7 days duration, imaged on OCT at various time points. Based on the OCT findings at presentation, cases were classified into three severity groups: mild, moderate, and severe. OCT scans were evaluated and classified into four-time intervals based on symptom duration. Results There were 39 eyes from 38 patients with acute CRAO who underwent 96 OCT scans. At presentation, the study had 11, 16, and 12 cases of mild, moderate, and severe CRAO, respectively. Middle retinal layer opacification was more common in mild CRAO cases, which caused inner retinal layer thinning over time. Moderate CRAO cases had total inner retinal layer opacification, which resulted in retinal thinning over time. Prominent middle limiting membrane (p-MLM) sign was seen in mild and moderate CRAO eyes while were not visualised in severe CRAO. This sign gradually faded out over time. Other OCT findings in higher grades of CRAO included inner retinal fluid, neurosensory detachment, internal limiting membrane detachment, hyperreflective foci, and posterior vitreous opacities. Regardless of the CRAO grade, the final end-point seen was inner retinal layer thinning over time. Conclusion OCT in CRAO is a useful for determining the severity of retinal ischemia, disease stage, tissue damage mechanism, and final visual outcome. More prospective studies analysing a larger number of cases at fixed time points will be required in the future. Trial Registration Trial Registration Number: Not applicable.https://doi.org/10.1186/s40942-023-00475-8Central retinal artery occlusionTemporal changesOptical coherence tomographyInner retina |
| spellingShingle | Rubble Mangla Ramesh Venkatesh Rohini Sangoram Isha Acharya Yash Parmar Vishma Prabhu Naresh Kumar Yadav Jay Chhablani Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational study International Journal of Retina and Vitreous Central retinal artery occlusion Temporal changes Optical coherence tomography Inner retina |
| title | Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational study |
| title_full | Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational study |
| title_fullStr | Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational study |
| title_full_unstemmed | Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational study |
| title_short | Retinal OCT findings in acute central retinal artery occlusion of varying severity at different disease stages – a retrospective, observational study |
| title_sort | retinal oct findings in acute central retinal artery occlusion of varying severity at different disease stages a retrospective observational study |
| topic | Central retinal artery occlusion Temporal changes Optical coherence tomography Inner retina |
| url | https://doi.org/10.1186/s40942-023-00475-8 |
| work_keys_str_mv | AT rubblemangla retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy AT rameshvenkatesh retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy AT rohinisangoram retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy AT ishaacharya retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy AT yashparmar retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy AT vishmaprabhu retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy AT nareshkumaryadav retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy AT jaychhablani retinaloctfindingsinacutecentralretinalarteryocclusionofvaryingseverityatdifferentdiseasestagesaretrospectiveobservationalstudy |