NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

Abstract Background High-throughput gene expression technologies provide complex datasets reflecting mechanisms perturbed in an experiment, typically in a treatment versus control design. Analysis of these information-rich data can be guided based on a priori knowledge, such as networks of related p...

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Bibliographic Details
Main Authors: Florian Martin, Sylvain Gubian, Marja Talikka, Julia Hoeng, Manuel C. Peitsch
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Bioinformatics
Subjects:
Gene expression
Network models
Systems toxicology
Online Access:http://link.springer.com/article/10.1186/s12859-019-3016-x

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