Time-of-day determines neuronal damage and mortality after cardiac arrest

Time-of-day determines neuronal damage and mortality after cardiac arrest

Ischemic events in humans are not evenly distributed across the day. To discriminate between temporal differences in the incidence of ischemia and susceptibility to ischemic events, we examined the outcome of global ischemia in a murine model at three time points during the day. Global cerebral isch...

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Bibliographic Details
Main Authors: Zachary M. Weil, Kate Karelina, Alan J. Su, Jacqueline M. Barker, Greg J. Norman, Ning Zhang, A. Courtney DeVries, Randy J. Nelson
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neurobiology of Disease
Subjects:
Global ischemia
Circadian rhythms
Microglia
Proinflammatory cytokines
Cardiac arrest
Heart disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002101

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