Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography
The presence of calcified plaques is one of the pathological phenotypes of acute coronary syndrome (ACS) and can be frequently found in culprit lesion segments. Trimethylamine N-oxide (TMAO) is reported to be involved in vascular calcification and plaque instability. This study investigated the rela...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.628471/full |
| _version_ | 1818414432296894464 |
|---|---|
| author | Jiannan Li Yu Tan Yu Tan Peng Zhou Chen Liu Hanjun Zhao Li Song Jinying Zhou Runzhen Chen Ying Wang Xiaoxiao Zhao Yi Chen Hongbing Yan Hongbing Yan |
| author_facet | Jiannan Li Yu Tan Yu Tan Peng Zhou Chen Liu Hanjun Zhao Li Song Jinying Zhou Runzhen Chen Ying Wang Xiaoxiao Zhao Yi Chen Hongbing Yan Hongbing Yan |
| author_sort | Jiannan Li |
| collection | DOAJ |
| description | The presence of calcified plaques is one of the pathological phenotypes of acute coronary syndrome (ACS) and can be frequently found in culprit lesion segments. Trimethylamine N-oxide (TMAO) is reported to be involved in vascular calcification and plaque instability. This study investigated the relationship between plasma TMAO levels and calcified lesions in culprit lesion segments in STEMI patients. A prospective series of 179 patients with STEMI were enrolled, and calcified lesions from 127 patients were analyzed by OCT. The plasma TMAO levels were measured by using stable isotope dilution liquid chromatography tandem mass spectrometry. Patients were divided into two groups according to the median plasma TMAO level. The prevalence of intimal calcified lesions in the high TMAO group was significantly higher than that in the low TMAO group (90.6 vs. 57.1%, p < 0.001; 84.4 vs. 44.4%, p < 0.001). After adjustment of traditional risk factors and medication history, patients with calcification in their culprit lesion segments had higher plasma TMAO levels than those without calcification. Moreover, plasma TMAO levels were significantly positively associated with the parameters of calcium burden, including maximal calcification arc (r = 0.392, p < 0.001), maximal calcification thickness (r = 0.443, p < 0.001), and calcified length (r = 0.466, p < 0.001). These results suggested that the level of TMAO is significantly correlated with the incidence of calcification in the culprit lesion segment, and the measurement of TMAO levels might improve clinical management in patients with heavy calcification.Clinical Trial Registration: This study is registered at ClinicalTrials.gov as NCT03593928. |
| first_indexed | 2024-12-14T11:19:00Z |
| format | Article |
| id | doaj.art-92345fa0f6304c0f88bcba1851369cd4 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-14T11:19:00Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-92345fa0f6304c0f88bcba1851369cd42022-12-21T23:03:51ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-02-01810.3389/fcvm.2021.628471628471Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence TomographyJiannan Li0Yu Tan1Yu Tan2Peng Zhou3Chen Liu4Hanjun Zhao5Li Song6Jinying Zhou7Runzhen Chen8Ying Wang9Xiaoxiao Zhao10Yi Chen11Hongbing Yan12Hongbing Yan13Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaXiamen Cardiovascular Hospital, Xiamen University, Fujian, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaFuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, ChinaThe presence of calcified plaques is one of the pathological phenotypes of acute coronary syndrome (ACS) and can be frequently found in culprit lesion segments. Trimethylamine N-oxide (TMAO) is reported to be involved in vascular calcification and plaque instability. This study investigated the relationship between plasma TMAO levels and calcified lesions in culprit lesion segments in STEMI patients. A prospective series of 179 patients with STEMI were enrolled, and calcified lesions from 127 patients were analyzed by OCT. The plasma TMAO levels were measured by using stable isotope dilution liquid chromatography tandem mass spectrometry. Patients were divided into two groups according to the median plasma TMAO level. The prevalence of intimal calcified lesions in the high TMAO group was significantly higher than that in the low TMAO group (90.6 vs. 57.1%, p < 0.001; 84.4 vs. 44.4%, p < 0.001). After adjustment of traditional risk factors and medication history, patients with calcification in their culprit lesion segments had higher plasma TMAO levels than those without calcification. Moreover, plasma TMAO levels were significantly positively associated with the parameters of calcium burden, including maximal calcification arc (r = 0.392, p < 0.001), maximal calcification thickness (r = 0.443, p < 0.001), and calcified length (r = 0.466, p < 0.001). These results suggested that the level of TMAO is significantly correlated with the incidence of calcification in the culprit lesion segment, and the measurement of TMAO levels might improve clinical management in patients with heavy calcification.Clinical Trial Registration: This study is registered at ClinicalTrials.gov as NCT03593928.https://www.frontiersin.org/articles/10.3389/fcvm.2021.628471/fulltrimethylamine N-oxidecalcified lesionoptical coherence tomographyST- segment elevation myocardial infarctionbiomarker |
| spellingShingle | Jiannan Li Yu Tan Yu Tan Peng Zhou Chen Liu Hanjun Zhao Li Song Jinying Zhou Runzhen Chen Ying Wang Xiaoxiao Zhao Yi Chen Hongbing Yan Hongbing Yan Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography Frontiers in Cardiovascular Medicine trimethylamine N-oxide calcified lesion optical coherence tomography ST- segment elevation myocardial infarction biomarker |
| title | Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography |
| title_full | Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography |
| title_fullStr | Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography |
| title_full_unstemmed | Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography |
| title_short | Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography |
| title_sort | association of trimethylamine n oxide levels and calcification in culprit lesion segments in patients with st segment elevation myocardial infarction evaluated by optical coherence tomography |
| topic | trimethylamine N-oxide calcified lesion optical coherence tomography ST- segment elevation myocardial infarction biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.628471/full |
| work_keys_str_mv | AT jiannanli associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT yutan associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT yutan associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT pengzhou associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT chenliu associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT hanjunzhao associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT lisong associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT jinyingzhou associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT runzhenchen associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT yingwang associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT xiaoxiaozhao associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT yichen associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT hongbingyan associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography AT hongbingyan associationoftrimethylaminenoxidelevelsandcalcificationinculpritlesionsegmentsinpatientswithstsegmentelevationmyocardialinfarctionevaluatedbyopticalcoherencetomography |