Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers

Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers

BackgroundFBXW7 is recognized as a critical tumor suppressor gene and a component of the ubiquitin-proteasome system, mediating the degradation of multiple oncogenic proteins, including c-MYC, Cyclin E, c-Jun, Notch, p53. Around 16% of colorectal cancer (CRC) patients carried FBXW7 somatic mutations...

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Bibliographic Details
Main Authors: Yiping Liu, Hanlin Chen, Hua Bao, Jinfeng Zhang, Runda Wu, Lingjun Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
Fbxw7
colorectal cancer
next generation sequencing - NGS
biomarker
GSEA analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1154432/full

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