Current data on IL-17 and Th17 cells and implications for graft versus host disease
Human interleukin 17 was first described in 1995 as a new cytokine produced primarily by activated T CD4+ cells that stimulate the secretion of IL-6 and IL-8 by human fibroblasts, besides increasing the expression of ICAM-1. Various authors have reported that IL-17A has a role in the protection of o...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
|
| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082013000200019&lng=en&tlng=en |
| _version_ | 1819062334455283712 |
|---|---|
| author | Marília Normanton Luciana Cavalheiro Marti |
| author_facet | Marília Normanton Luciana Cavalheiro Marti |
| author_sort | Marília Normanton |
| collection | DOAJ |
| description | Human interleukin 17 was first described in 1995 as a new cytokine produced primarily by activated T CD4+ cells that stimulate the secretion of IL-6 and IL-8 by human fibroblasts, besides increasing the expression of ICAM-1. Various authors have reported that IL-17A has a role in the protection of organisms against extracellular bacteria and fungi due to the capacity of IL-17A to recruit neutrophils to the areas of infection, evidencing a pathological role in various models of autoimmune diseases, such as experimental autoimmune encephalitis and arthritis. The participation of IL-17A has also been described in the acute rejection of organ transplants and graft versus host disease. However, the greatest revolution in research with IL-17 happened in 2000, when it was proposed that IL-17 cannot be classified as Th1 or Th2, but rather, simply as a new lineage of IL-17-producing T-cells. These findings modified the previously established Th1/Th2 paradigm, leading to the definition of the CD3+ CD4+ Th17 cellular subtype and establishment of a new model to explain the origin of various immune events, as well as its implication in the graft versus host disease that is discussed in depth in this article. |
| first_indexed | 2024-12-21T14:57:08Z |
| format | Article |
| id | doaj.art-92375f4ef9954e48b281383b4c943bef |
| institution | Directory Open Access Journal |
| issn | 1679-4508 2317-6385 |
| language | English |
| last_indexed | 2024-12-21T14:57:08Z |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-92375f4ef9954e48b281383b4c943bef2022-12-21T18:59:42ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082317-638511223724610.1590/S1679-45082013000200019S1679-45082013000200019Current data on IL-17 and Th17 cells and implications for graft versus host diseaseMarília Normanton0Luciana Cavalheiro Marti1Hospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHuman interleukin 17 was first described in 1995 as a new cytokine produced primarily by activated T CD4+ cells that stimulate the secretion of IL-6 and IL-8 by human fibroblasts, besides increasing the expression of ICAM-1. Various authors have reported that IL-17A has a role in the protection of organisms against extracellular bacteria and fungi due to the capacity of IL-17A to recruit neutrophils to the areas of infection, evidencing a pathological role in various models of autoimmune diseases, such as experimental autoimmune encephalitis and arthritis. The participation of IL-17A has also been described in the acute rejection of organ transplants and graft versus host disease. However, the greatest revolution in research with IL-17 happened in 2000, when it was proposed that IL-17 cannot be classified as Th1 or Th2, but rather, simply as a new lineage of IL-17-producing T-cells. These findings modified the previously established Th1/Th2 paradigm, leading to the definition of the CD3+ CD4+ Th17 cellular subtype and establishment of a new model to explain the origin of various immune events, as well as its implication in the graft versus host disease that is discussed in depth in this article.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082013000200019&lng=en&tlng=enil-17th17graft-host disease |
| spellingShingle | Marília Normanton Luciana Cavalheiro Marti Current data on IL-17 and Th17 cells and implications for graft versus host disease Einstein (São Paulo) il-17 th17 graft-host disease |
| title | Current data on IL-17 and Th17 cells and implications for graft versus host disease |
| title_full | Current data on IL-17 and Th17 cells and implications for graft versus host disease |
| title_fullStr | Current data on IL-17 and Th17 cells and implications for graft versus host disease |
| title_full_unstemmed | Current data on IL-17 and Th17 cells and implications for graft versus host disease |
| title_short | Current data on IL-17 and Th17 cells and implications for graft versus host disease |
| title_sort | current data on il 17 and th17 cells and implications for graft versus host disease |
| topic | il-17 th17 graft-host disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082013000200019&lng=en&tlng=en |
| work_keys_str_mv | AT marilianormanton currentdataonil17andth17cellsandimplicationsforgraftversushostdisease AT lucianacavalheiromarti currentdataonil17andth17cellsandimplicationsforgraftversushostdisease |