5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells

5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells

Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition...

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Bibliographic Details
Main Authors: Ewa Żesławska, Waldemar Tejchman, Annamária Kincses, Gabriella Spengler, Wojciech Nitek, Grzegorz Żuchowski, Ewa Szymańska
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
cancer multidrug resistance
P-glycoprotein
efflux pump inhibition
rhodanine
T-lymphoma cancer cells
crystal structure
Online Access:https://www.mdpi.com/1422-0067/23/18/10812

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