Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study
BackgroundSleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population. ObjectiveThis s...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JMIR Publications
2024-03-01
|
| Series: | JMIR Research Protocols |
| Online Access: | https://www.researchprotocols.org/2024/1/e52652 |
| _version_ | 1797248694036201472 |
|---|---|
| author | Victoria Grace Gabb Jonathan Blackman Hamish Duncan Morrison Bijetri Biswas Haoxuan Li Nicholas Turner Georgina M Russell Rosemary Greenwood Amy Jolly William Trender Adam Hampshire Alan Whone Elizabeth Coulthard |
| author_facet | Victoria Grace Gabb Jonathan Blackman Hamish Duncan Morrison Bijetri Biswas Haoxuan Li Nicholas Turner Georgina M Russell Rosemary Greenwood Amy Jolly William Trender Adam Hampshire Alan Whone Elizabeth Coulthard |
| author_sort | Victoria Grace Gabb |
| collection | DOAJ |
| description |
BackgroundSleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population.
ObjectiveThis study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD.
MethodsWe will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment. Adults aged older than 50 years who were diagnosed with mild to moderate dementia or mild cognitive impairment (MCI) due to probable AD or LBD and age-matched controls will be eligible. Exclusion criteria include lack of capacity to consent to research, other causes of MCI or dementia, and clinically significant sleep disorders. Participants will complete a cognitive assessment and questionnaires with a researcher and receive training and instructions for at-home study tasks across 8 weeks. At-home study tasks include remote sleep assessments using wearable devices (electroencephalography headband and actigraphy watch), app-based sleep diaries, online cognitive assessments, and saliva samples for melatonin- and cortisol-derived circadian markers. Feasibility outcomes will be assessed relating to recruitment and retention, data completeness, data quality, and support required. Feedback on acceptability and usability will be collected throughout the study period and end-of-study interviews will be analyzed using thematic analysis.
ResultsRecruitment started in February 2022. Data collection is ongoing, with final data expected in February 2024 and data analysis and publication of findings scheduled for the summer of 2024.
ConclusionsThis study will allow us to assess if remote testing using smart devices and wearable technology is a viable alternative to traditional sleep measurements, such as polysomnography and questionnaires, in older adults with and without MCI or dementia due to AD or LBD. Understanding participant experience and the barriers and facilitators to technology use for research purposes and remote research in this population will assist with the development of, recruitment to, and retention within future research projects studying sleep and cognition outside of the clinic or laboratory.
International Registered Report Identifier (IRRID)DERR1-10.2196/52652 |
| first_indexed | 2024-04-24T20:18:39Z |
| format | Article |
| id | doaj.art-923ba9939b084519bb10486f759628ac |
| institution | Directory Open Access Journal |
| issn | 1929-0748 |
| language | English |
| last_indexed | 2024-04-24T20:18:39Z |
| publishDate | 2024-03-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Research Protocols |
| spelling | doaj.art-923ba9939b084519bb10486f759628ac2024-03-22T12:30:39ZengJMIR PublicationsJMIR Research Protocols1929-07482024-03-0113e5265210.2196/52652Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods StudyVictoria Grace Gabbhttps://orcid.org/0000-0002-7688-766XJonathan Blackmanhttps://orcid.org/0000-0001-9579-9860Hamish Duncan Morrisonhttps://orcid.org/0000-0001-9358-7936Bijetri Biswashttps://orcid.org/0000-0003-3995-2693Haoxuan Lihttps://orcid.org/0009-0008-7120-8657Nicholas Turnerhttps://orcid.org/0000-0003-1591-6997Georgina M Russellhttps://orcid.org/0000-0002-1299-4116Rosemary Greenwoodhttps://orcid.org/0000-0001-6637-5225Amy Jollyhttps://orcid.org/0000-0002-7413-9772William Trenderhttps://orcid.org/0000-0003-3947-5532Adam Hampshirehttps://orcid.org/0000-0002-5176-5420Alan Whonehttps://orcid.org/0000-0002-8931-4422Elizabeth Coulthardhttps://orcid.org/0000-0002-0017-9595 BackgroundSleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population. ObjectiveThis study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD. MethodsWe will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment. Adults aged older than 50 years who were diagnosed with mild to moderate dementia or mild cognitive impairment (MCI) due to probable AD or LBD and age-matched controls will be eligible. Exclusion criteria include lack of capacity to consent to research, other causes of MCI or dementia, and clinically significant sleep disorders. Participants will complete a cognitive assessment and questionnaires with a researcher and receive training and instructions for at-home study tasks across 8 weeks. At-home study tasks include remote sleep assessments using wearable devices (electroencephalography headband and actigraphy watch), app-based sleep diaries, online cognitive assessments, and saliva samples for melatonin- and cortisol-derived circadian markers. Feasibility outcomes will be assessed relating to recruitment and retention, data completeness, data quality, and support required. Feedback on acceptability and usability will be collected throughout the study period and end-of-study interviews will be analyzed using thematic analysis. ResultsRecruitment started in February 2022. Data collection is ongoing, with final data expected in February 2024 and data analysis and publication of findings scheduled for the summer of 2024. ConclusionsThis study will allow us to assess if remote testing using smart devices and wearable technology is a viable alternative to traditional sleep measurements, such as polysomnography and questionnaires, in older adults with and without MCI or dementia due to AD or LBD. Understanding participant experience and the barriers and facilitators to technology use for research purposes and remote research in this population will assist with the development of, recruitment to, and retention within future research projects studying sleep and cognition outside of the clinic or laboratory. International Registered Report Identifier (IRRID)DERR1-10.2196/52652https://www.researchprotocols.org/2024/1/e52652 |
| spellingShingle | Victoria Grace Gabb Jonathan Blackman Hamish Duncan Morrison Bijetri Biswas Haoxuan Li Nicholas Turner Georgina M Russell Rosemary Greenwood Amy Jolly William Trender Adam Hampshire Alan Whone Elizabeth Coulthard Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study JMIR Research Protocols |
| title | Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study |
| title_full | Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study |
| title_fullStr | Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study |
| title_full_unstemmed | Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study |
| title_short | Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study |
| title_sort | remote evaluation of sleep and circadian rhythms in older adults with mild cognitive impairment and dementia protocol for a feasibility and acceptability mixed methods study |
| url | https://www.researchprotocols.org/2024/1/e52652 |
| work_keys_str_mv | AT victoriagracegabb remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT jonathanblackman remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT hamishduncanmorrison remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT bijetribiswas remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT haoxuanli remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT nicholasturner remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT georginamrussell remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT rosemarygreenwood remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT amyjolly remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT williamtrender remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT adamhampshire remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT alanwhone remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy AT elizabethcoulthard remoteevaluationofsleepandcircadianrhythmsinolderadultswithmildcognitiveimpairmentanddementiaprotocolforafeasibilityandacceptabilitymixedmethodsstudy |