Autophagy Inhibitor Chloroquine Downmodulates Hepatic Stellate Cell Activation and Liver Damage in Bile-Duct-Ligated Mice

Autophagy Inhibitor Chloroquine Downmodulates Hepatic Stellate Cell Activation and Liver Damage in Bile-Duct-Ligated Mice

Hepatic stellate cell (HSC) activation via the autophagy pathway is a critical factor in liver fibrogenesis. This study tests the hypothesis that chloroquine (CQ) treatment can prevent autophagy and HSC activation in vitro and in vivo in bile-duct-ligated (BDL) mice. Sham-operated and BDL mice were...

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Bibliographic Details
Main Authors: Trinh Van Le, Hong-Thuy Phan-Thi, My-Xuan Huynh-Thi, Thanh Minh Dang, Ai Xuan Le Holterman, Gabriele Grassi, Thao-Uyen Nguyen-Luu, Nhung Hai Truong
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
anti-fibrosis
autophagy
bile duct ligation
chloroquine
stellate cell transformation
Online Access:https://www.mdpi.com/2073-4409/12/7/1025

Internet

https://www.mdpi.com/2073-4409/12/7/1025

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