TACI Isoforms Regulate Ligand Binding and Receptor Function

TACI Isoforms Regulate Ligand Binding and Receptor Function

TACI signals activate B cell proliferation, isotype switch and antibody production in both normal immunity and autoimmune states. In contrast to murine TACI, the human TACI gene undergoes alternative splicing to produce short and long isoforms (TACI-S and TACI-L). In previous studies, we showed that...

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Bibliographic Details
Main Authors: Yolanda Garcia-Carmona, Adrian T. Ting, Lin Radigan, Sai Krishna Athuluri Divakar, Jose Chavez, Eric Meffre, Andrea Cerutti, Charlotte Cunningham-Rundles
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
TACI
isoforms
B cell
activation
TLR9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02125/full

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