Estimation of the Mutagenic Potential of 8-Oxog in Nuclear Extracts of Mouse Cells Using the “Framed Mirror” Method

Estimation of the Mutagenic Potential of 8-Oxog in Nuclear Extracts of Mouse Cells Using the “Framed Mirror” Method

We propose an improved earlier described “mirror” method for detecting in cell nuclear extracts mutations that arise in DNA during its replication due to the misincorporation of deoxyadenosine-5′-monophosphate (dAMP) opposite 7,8-dihydro-8-oxoguanine (8-oxoG). This meth...

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Bibliographic Details
Main Authors:	Leonid V. Gening, Alexandr A. Volodin, Konstantin Y. Kazachenko, Irina V. Makarova, Vyacheslav Z. Tarantul
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Methods and Protocols
Subjects:	dna lesions 7,8-dihydro-8-oxoguanine (8-oxog) mutagenic activity method of detection cell nuclear extracts mice organs and embryos
Online Access:	https://www.mdpi.com/2409-9279/3/1/3

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