A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs

A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs

Background: Hypotensive resuscitation is widely applied for trauma and war injury to reduce bleeding during damage-control resuscitation, but the treatment time window is limited in order to avoid hypoxia-associated organ injury. Whether a novel hemoglobin-based oxygen carrier (HBOC), YQ23 in this s...

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Bibliographic Details
Main Authors: Lei Kuang, Yu Zhu, Yue Wu, Kunlun Tian, Xiaoyong Peng, Mingying Xue, Xinming Xiang, Billy Lau, Fei Chuen Tzang, Liangming Liu, Tao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
hemoglobin-based oxygen carrier (HBOC)
uncontrolled hemorrhagic shock
fluid resuscitation
early treatment
oxygen delivery
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.652716/full

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